YDR386W

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Systematic name YDR386W
Gene name MUS81
Aliases SLX3
Feature type ORF, Verified
Coordinates Chr IV:1246077..1247975
Primary SGDID S000002794


Description of YDR386W: Helix-hairpin-helix protein, involved in DNA repair and replication fork stability; functions as an endonuclease in complex with Mms4p; interacts with Rad54p[1][2][3]




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References

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  1. Fu Y and Xiao W (2003) Functional domains required for the Saccharomyces cerevisiae Mus81-Mms4 endonuclease complex formation and nuclear localization. DNA Repair (Amst) 2(12):1435-47 SGD PMID 14642571
  2. Bastin-Shanower SA, et al. (2003) The mechanism of Mus81-Mms4 cleavage site selection distinguishes it from the homologous endonuclease Rad1-Rad10. Mol Cell Biol 23(10):3487-96 SGD PMID 12724407
  3. Interthal H and Heyer WD (2000) MUS81 encodes a novel helix-hairpin-helix protein involved in the response to UV- and methylation-induced DNA damage in Saccharomyces cerevisiae. Mol Gen Genet 263(5):812-27 SGD PMID 10905349

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