Difference between revisions of "YDR346C"

From SGD-Wiki
Jump to: navigation, search
(Automated import of articles)
(Automated import of articles)
Line 38: Line 38:
  
 
{{ShortCenteredHR}}
 
{{ShortCenteredHR}}
 +
 +
 +
 +
<!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation -->
 +
<!--
 +
Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
 +
<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
 +
J Biol Chem 278(5):3265-74</ref>
 +
-->
  
 
<protect>
 
<protect>

Revision as of 13:02, 21 February 2007

Share your knowledge...Edit this entry! <protect>

Systematic name YDR346C
Gene name SVF1
Aliases SGI1
Feature type ORF, Verified
Coordinates Chr IV:1168653..1167208


Description of YDR346C: Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis[1]




</protect>

Community Commentary

About Community Commentary. Please share your knowledge!

Alleles, Strains, and Phenotypes

Complete Deletion

Strain Background: W303
Phenotype(s): Loss of function (Null), Temperature(Heat) Sensitive

Mutant shows decreased growth in glycerol and decreased ability to undergo diauxic shift. These phenotypes are corrected by expression of Bcl-xL. (Conversely, YDR346C has anti-apoptotic activity when expressed in mammalian cells.) Authors have named the gene SVF1, and found homology only to other fungal genes. They suggest that SVF1 may represent an as yet unknown family of genes responsible for adaptation to cellular stress. [1] [2]




<protect>

References

See Help:References on how to add references

  1. 1.0 1.1 Vander Heiden MG, et al. (2002) Bcl-x(L) complements Saccharomyces cerevisiae genes that facilitate the switch from glycolytic to oxidative metabolism. J Biol Chem 277(47):44870-6 SGD PMID 12244097 Cite error: Invalid <ref> tag; name "S000071715" defined multiple times with different content
  2. submitted by Matthew Brauer on 2003-08-28

See Help:Categories on how to add the wiki page for this gene to a Category </protect>