Difference between revisions of "YDR310C"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YDR310C YDR310C]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002718 YDR310C]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''SUM1 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''SUM1 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
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|nowrap| Chr IV:1084312..1081124
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|nowrap| Chr IV:1084316..1081128
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000002718
 
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'''Description of {{PAGENAME}}:''' Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; involved in telomere maintenance, regulated by the pachytene checkpoint<ref name='S000114270'>Askree SH, et al. (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63 {{SGDpaper|S000114270}} PMID 15161972</ref><ref name='S000059406'>Lindgren A, et al. (2000) The pachytene checkpoint in Saccharomyces cerevisiae requires the Sum1 transcriptional repressor. EMBO J 19(23):6489-97 {{SGDpaper|S000059406}} PMID 11101521</ref><ref name='S000047356'>Laurenson P and Rine J (1991) SUM1-1: a suppressor of silencing defects in Saccharomyces cerevisiae. Genetics 129(3):685-96 {{SGDpaper|S000047356}} PMID 1752414</ref><ref name='S000046332'>Klar AJ, et al. (1985) SUM1, an apparent positive regulator of the cryptic mating-type loci in Saccharomyces cerevisiae. Genetics 111(4):745-58 {{SGDpaper|S000046332}} PMID 3905506</ref><ref name='S000040525'>Xie J, et al. (1999) Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae. EMBO J 18(22):6448-54
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'''Description of YDR310C:''' Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint<ref name='S000114270'>Askree SH, et al. (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63 {{SGDpaper|S000114270}} PMID 15161972</ref><ref name='S000086031'>Irlbacher H, et al. (2005) Control of replication initiation and heterochromatin formation in Saccharomyces cerevisiae by a regulator of meiotic gene expression. Genes Dev 19(15):1811-22 {{SGDpaper|S000086031}} PMID 16077008</ref><ref name='S000046332'>Klar AJ, et al. (1985) SUM1, an apparent positive regulator of the cryptic mating-type loci in Saccharomyces cerevisiae. Genetics 111(4):745-58 {{SGDpaper|S000046332}} PMID 3905506</ref><ref name='S000047356'>Laurenson P and Rine J (1991) SUM1-1: a suppressor of silencing defects in Saccharomyces cerevisiae. Genetics 129(3):685-96 {{SGDpaper|S000047356}} PMID 1752414</ref><ref name='S000059406'>Lindgren A, et al. (2000) The pachytene checkpoint in Saccharomyces cerevisiae requires the Sum1 transcriptional repressor. EMBO J 19(23):6489-97 {{SGDpaper|S000059406}} PMID 11101521</ref><ref name='S000040525'>Xie J, et al. (1999) Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae. EMBO J 18(22):6448-54
 
  {{SGDpaper|S000040525}} PMID 10562556</ref>
 
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=== Interactions ===
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==== Physical ====
 
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Physical interaction with Hst1 [[Category:Physical Interactions with Hst1]]<br>
 
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Sum1, a repressor of middle meiotic genes, was found to interact with Hst1 by coimmunoprecipitation. A neomorphic allele of Sum1 (Sum1-1) also interacts with Hst1. Hst1 is a histone deacetylase, and it is required for repression of some Sum1 targets. <ref name='S000060164'>Rusche LN and Rine J (2001) Conversion of a gene-specific repressor to a regional silencer. Genes Dev 15(8):955-67 {{SGDpaper|S000060164}} PMID 11316790</ref> <ref name = 'CAset9199-2003-03-14'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9199 Hunter Fraser] on 2003-03-14</ref>
 
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==Community Commentary==
 
==Community Commentary==
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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==References==
 
==References==
 
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Latest revision as of 07:45, 23 January 2012

Share your knowledge...Edit this entry! <protect>

Systematic name YDR310C
Gene name SUM1
Aliases
Feature type ORF, Verified
Coordinates Chr IV:1084316..1081128
Primary SGDID S000002718


Description of YDR310C: Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint[1][2][3][4][5][6]




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Community Commentary

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Interactions

Physical

Physical interaction with Hst1
Sum1, a repressor of middle meiotic genes, was found to interact with Hst1 by coimmunoprecipitation. A neomorphic allele of Sum1 (Sum1-1) also interacts with Hst1. Hst1 is a histone deacetylase, and it is required for repression of some Sum1 targets. [7] [8]




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References

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  1. ↑ Askree SH, et al. (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63 SGD PMID 15161972
  2. ↑ Irlbacher H, et al. (2005) Control of replication initiation and heterochromatin formation in Saccharomyces cerevisiae by a regulator of meiotic gene expression. Genes Dev 19(15):1811-22 SGD PMID 16077008
  3. ↑ Klar AJ, et al. (1985) SUM1, an apparent positive regulator of the cryptic mating-type loci in Saccharomyces cerevisiae. Genetics 111(4):745-58 SGD PMID 3905506
  4. ↑ Laurenson P and Rine J (1991) SUM1-1: a suppressor of silencing defects in Saccharomyces cerevisiae. Genetics 129(3):685-96 SGD PMID 1752414
  5. ↑ Lindgren A, et al. (2000) The pachytene checkpoint in Saccharomyces cerevisiae requires the Sum1 transcriptional repressor. EMBO J 19(23):6489-97 SGD PMID 11101521
  6. ↑ Xie J, et al. (1999) Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae. EMBO J 18(22):6448-54 SGD PMID 10562556
  7. ↑ Rusche LN and Rine J (2001) Conversion of a gene-specific repressor to a regional silencer. Genes Dev 15(8):955-67 SGD PMID 11316790
  8. ↑ submitted by Hunter Fraser on 2003-03-14

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