Difference between revisions of "YDR293C"
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| − | '''Description of YDR293C:''' Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components<ref name='S000132503'>Jansen JM, et al. (2009) Cbk1 regulation of the RNA-binding protein Ssd1 integrates cell fate with translational control. Curr Biol 19(24):2114-20 {{SGDpaper|S000132503}} PMID 19962308</ref><ref name='S000069081'>Kaeberlein M and Guarente L (2002) Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity. Genetics 160(1):83-95 {{SGDpaper|S000069081}} PMID 11805047</ref><ref name='S000144483'>Kurischko C, et al. (2011) The yeast Cbk1 kinase regulates mRNA localization via the mRNA-binding protein Ssd1. J Cell Biol 192(4):583-98 {{SGDpaper|S000144483}} PMID 21339329</ref><ref name='S000139087'>Ohyama Y, et al. (2010) Saccharomyces cerevisiae Ssd1p promotes CLN2 expression by binding to the 5'-untranslated region of CLN2 mRNA. Genes Cells 15(12):1169-88 {{SGDpaper|S000139087}} PMID 20977549</ref><ref name='S000075967'>Reinke A, et al. (2004) TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae. J Biol Chem 279(15):14752-62 | + | '''Description of YDR293C:''' Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function<ref name='S000132503'>Jansen JM, et al. (2009) Cbk1 regulation of the RNA-binding protein Ssd1 integrates cell fate with translational control. Curr Biol 19(24):2114-20 {{SGDpaper|S000132503}} PMID 19962308</ref><ref name='S000069081'>Kaeberlein M and Guarente L (2002) Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity. Genetics 160(1):83-95 {{SGDpaper|S000069081}} PMID 11805047</ref><ref name='S000146131'>Kurischko C, et al. (2011) Nucleocytoplasmic shuttling of Ssd1 defines the destiny of its bound mRNAs.LID - 10.1111/j.1365-2958.2011.07731.x [doi] Mol Microbiol () {{SGDpaper|S000146131}} PMID 21762218</ref><ref name='S000144483'>Kurischko C, et al. (2011) The yeast Cbk1 kinase regulates mRNA localization via the mRNA-binding protein Ssd1. J Cell Biol 192(4):583-98 {{SGDpaper|S000144483}} PMID 21339329</ref><ref name='S000139087'>Ohyama Y, et al. (2010) Saccharomyces cerevisiae Ssd1p promotes CLN2 expression by binding to the 5'-untranslated region of CLN2 mRNA. Genes Cells 15(12):1169-88 {{SGDpaper|S000139087}} PMID 20977549</ref><ref name='S000075967'>Reinke A, et al. (2004) TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae. J Biol Chem 279(15):14752-62 |
{{SGDpaper|S000075967}} PMID 14736892</ref> | {{SGDpaper|S000075967}} PMID 14736892</ref> | ||
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Revision as of 14:05, 12 October 2011
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| Systematic name | YDR293C |
| Gene name | SSD1 |
| Aliases | CLA1, MCS1, RLT1, SRK1 |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:1049392..1045640 |
| Primary SGDID | S000002701 |
Description of YDR293C: Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function[1][2][3][4][5][6]
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Community Commentary
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Strain W303 has ssd1-d2 allele[7] in which the 2094th nucleotide C is substituted with G, resulting in a premature stop codon[8], whereas S288C and BY4741 strains have dominant SSD1-V[9], which encodes a full-length Ssd1 protein.
--S.hiraga 16:19, 29 April 2010 (UTC)
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References
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- ↑ Jansen JM, et al. (2009) Cbk1 regulation of the RNA-binding protein Ssd1 integrates cell fate with translational control. Curr Biol 19(24):2114-20 SGD PMID 19962308
- ↑ Kaeberlein M and Guarente L (2002) Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity. Genetics 160(1):83-95 SGD PMID 11805047
- ↑ Kurischko C, et al. (2011) Nucleocytoplasmic shuttling of Ssd1 defines the destiny of its bound mRNAs.LID - 10.1111/j.1365-2958.2011.07731.x [doi] Mol Microbiol () SGD PMID 21762218
- ↑ Kurischko C, et al. (2011) The yeast Cbk1 kinase regulates mRNA localization via the mRNA-binding protein Ssd1. J Cell Biol 192(4):583-98 SGD PMID 21339329
- ↑ Ohyama Y, et al. (2010) Saccharomyces cerevisiae Ssd1p promotes CLN2 expression by binding to the 5'-untranslated region of CLN2 mRNA. Genes Cells 15(12):1169-88 SGD PMID 20977549
- ↑ Reinke A, et al. (2004) TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae. J Biol Chem 279(15):14752-62 SGD PMID 14736892
- ↑ Sutton et al. (1991) The SIT4 protein phosphatase functions in late G1 for progression into S phase. Mol Cell Biol 11(4):2133-48
- ↑ Jorgensen et al. (2002) High-Resolution Genetic Mapping With Ordered Arrays of Saccharomyces cerevisiae Deletion Mutants. Genetics 162(3):1091-9
- ↑ Sutton et al. (1991) The SIT4 protein phosphatase functions in late G1 for progression into S phase. Mol Cell Biol 11(4):2133-48
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References
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See Help:Categories on how to add the wiki page for this gene to a Category </protect>
