YDR265W

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Systematic name YDR265W
Gene name PEX10
Aliases PAS4
Feature type ORF, Verified
Coordinates Chr IV:998860..999873
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Description of YDR265W: RING finger peroxisomal membrane peroxin required for peroxisomal matrix protein import, interacts with Pex12p, links ubiquitin-conjugating Pex4p to protein import machinery; mutations in human homolog cause a variety of peroxisomal disorders[1][2][3][4]



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Protein Details

Other Protein Details

Other Topic: Homology

Homology was found, at the sequence and domain-composition level, between several components of the Peroxisomal protein import machinery and components of the Endoplasmic Reticulum Associated Decay (ERAD) pathway. This suggests a common evolutionary origin for both systems and a similar mechanism of action. The homology relationships can be stablished between Pex1,Pex6 and cdc48; Pex2 and Hrd1; Pex4 and Ubc1; and Pex5 and Hrd3. [5] [6]


References

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  1. Eckert JH and Johnsson N (2003) Pex10p links the ubiquitin conjugating enzyme Pex4p to the protein import machinery of the peroxisome. J Cell Sci 116(Pt 17):3623-34 SGD PMID 12876220
  2. Purdue PE and Lazarow PB (2001) Peroxisome biogenesis. Annu Rev Cell Dev Biol 17():701-52 SGD PMID 11687502
  3. Albertini M, et al. (2001) Pex12p of Saccharomyces cerevisiae is a component of a multi-protein complex essential for peroxisomal matrix protein import. Eur J Cell Biol 80(4):257-70 SGD PMID 11370741
  4. Warren DS, et al. (1998) Identification of PEX10, the gene defective in complementation group 7 of the peroxisome-biogenesis disorders. Am J Hum Genet 63(2):347-59 SGD PMID 9683594
  5. Gabaldon T, et al. (2006) Origin and evolution of the peroxisomal proteome. Biol Direct 1():8 SGD PMID 16556314
  6. submitted by Toni Gabaldon on 2006-04-12

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