Difference between revisions of "YDR265W"

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'''Description of YDR265W:''' C3HC4-type RING-finger peroxisomal membrane peroxin required for peroxisomal matrix protein import, interacts with Pex12p, links ubiquitin-conjugating Pex4p to import machinery; mutations in human homolog cause various peroxisomal disorders<ref name='S000073905'>Eckert JH and Johnsson N (2003) Pex10p links the ubiquitin conjugating enzyme Pex4p to the protein import machinery of the peroxisome. J Cell Sci 116(Pt 17):3623-34 {{SGDpaper|S000073905}} PMID 12876220</ref><ref name='S000069033'>Purdue PE and Lazarow PB (2001) Peroxisome biogenesis. Annu Rev Cell Dev Biol 17:701-52 {{SGDpaper|S000069033}} PMID 11687502</ref><ref name='S000060328'>Albertini M, et al. (2001) Pex12p of Saccharomyces cerevisiae is a component of a multi-protein complex essential for peroxisomal matrix protein import. Eur J Cell Biol 80(4):257-70 {{SGDpaper|S000060328}} PMID 11370741</ref><ref name='S000050645'>Warren DS, et al. (1998) Identification of PEX10, the gene defective in complementation group 7 of the peroxisome-biogenesis disorders. Am J Hum Genet 63(2):347-59
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'''Description of YDR265W:''' Peroxisomal membrane E3 ubiquitin ligase required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders<ref name='S000127135'>Williams C, et al. (2008) Pex10p functions as an E(3) ligase for the Ubc4p-dependent ubiquitination of Pex5p. Biochem Biophys Res Commun  {{SGDpaper|S000127135}} PMID 18644345</ref><ref name='S000073905'>Eckert JH and Johnsson N (2003) Pex10p links the ubiquitin conjugating enzyme Pex4p to the protein import machinery of the peroxisome. J Cell Sci 116(Pt 17):3623-34 {{SGDpaper|S000073905}} PMID 12876220</ref><ref name='S000069033'>Purdue PE and Lazarow PB (2001) Peroxisome biogenesis. Annu Rev Cell Dev Biol 17:701-52 {{SGDpaper|S000069033}} PMID 11687502</ref><ref name='S000060328'>Albertini M, et al. (2001) Pex12p of Saccharomyces cerevisiae is a component of a multi-protein complex essential for peroxisomal matrix protein import. Eur J Cell Biol 80(4):257-70 {{SGDpaper|S000060328}} PMID 11370741</ref><ref name='S000050645'>Warren DS, et al. (1998) Identification of PEX10, the gene defective in complementation group 7 of the peroxisome-biogenesis disorders. Am J Hum Genet 63(2):347-59
 
  {{SGDpaper|S000050645}} PMID 9683594</ref>
 
  {{SGDpaper|S000050645}} PMID 9683594</ref>
 
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Revision as of 14:05, 21 August 2008

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Systematic name YDR265W
Gene name PEX10
Aliases PAS4
Feature type ORF, Verified
Coordinates Chr IV:998861..999874
Primary SGDID S000002673


Description of YDR265W: Peroxisomal membrane E3 ubiquitin ligase required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders[1][2][3][4][5]




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Protein Details

Other Protein Details

Other Topic: Homology

Homology was found, at the sequence and domain-composition level, between several components of the Peroxisomal protein import machinery and components of the Endoplasmic Reticulum Associated Decay (ERAD) pathway. This suggests a common evolutionary origin for both systems and a similar mechanism of action. The homology relationships can be stablished between Pex1,Pex6 and cdc48; Pex2 and Hrd1; Pex4 and Ubc1; and Pex5 and Hrd3. [6] [7]





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References

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  1. Williams C, et al. (2008) Pex10p functions as an E(3) ligase for the Ubc4p-dependent ubiquitination of Pex5p. Biochem Biophys Res Commun SGD PMID 18644345
  2. Eckert JH and Johnsson N (2003) Pex10p links the ubiquitin conjugating enzyme Pex4p to the protein import machinery of the peroxisome. J Cell Sci 116(Pt 17):3623-34 SGD PMID 12876220
  3. Purdue PE and Lazarow PB (2001) Peroxisome biogenesis. Annu Rev Cell Dev Biol 17:701-52 SGD PMID 11687502
  4. Albertini M, et al. (2001) Pex12p of Saccharomyces cerevisiae is a component of a multi-protein complex essential for peroxisomal matrix protein import. Eur J Cell Biol 80(4):257-70 SGD PMID 11370741
  5. Warren DS, et al. (1998) Identification of PEX10, the gene defective in complementation group 7 of the peroxisome-biogenesis disorders. Am J Hum Genet 63(2):347-59 SGD PMID 9683594
  6. Gabaldon T, et al. (2006) Origin and evolution of the peroxisomal proteome. Biol Direct 1():8 SGD PMID 16556314
  7. submitted by Toni Gabaldon on 2006-04-12

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