YDR244W
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| Systematic name | YDR244W | |
| Gene name | PEX5 | |
| Aliases | PAS10 | |
| Feature type | ORF, Verified | |
| Coordinates | Chr IV:950559..952397 | |
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Description of YDR244W: Peroxisomal membrane signal receptor for C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import, tetratricopeptide repeat protein, also involved in PTS1-independent import[1][2][3][4][5]
Protein Details
Other Protein Details
Other Topic: Homology
Homology was found, at the sequence and domain-composition level, between several components of the Peroxisomal protein import machinery and components of the Endoplasmic Reticulum Associated Decay (ERAD) pathway. This suggests a common evolutionary origin for both systems and a similar mechanism of action. The homology relationships can be stablished between Pex1,Pex6 and cdc48; Pex2 and Hrd1; Pex4 and Ubc1; and Pex5 and Hrd3. [6] [7]
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Protein Details
Other Protein Details
Other Topic: Homology
Homology was found, at the sequence and domain-composition level, between several components of the Peroxisomal protein import machinery and components of the Endoplasmic Reticulum Associated Decay (ERAD) pathway. This suggests a common evolutionary origin for both systems and a similar mechanism of action. The homology relationships can be stablished between Pex1,Pex6 and cdc48; Pex2 and Hrd1; Pex4 and Ubc1; and Pex5 and Hrd3. [6] [7]
References
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- ↑ Klein AT, et al. (2002) Saccharomyces cerevisiae acyl-CoA oxidase follows a novel, non-PTS1, import pathway into peroxisomes that is dependent on Pex5p. J Biol Chem 277(28):25011-9 SGD PMID 11967269
- ↑ Van der Leij I, et al. (1993) PAS10 is a tetratricopeptide-repeat protein that is essential for the import of most matrix proteins into peroxisomes of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 90(24):11782-6 SGD PMID 8265627
- ↑ Fransen M, et al. (1995) Identification and characterization of the putative human peroxisomal C-terminal targeting signal import receptor. J Biol Chem 270(13):7731-6 SGD PMID 7706321
- ↑ Erdmann R and Blobel G (1996) Identification of Pex13p a peroxisomal membrane receptor for the PTS1 recognition factor. J Cell Biol 135(1):111-21 SGD PMID 8858167
- ↑ Brocard C, et al. (1994) The tetratricopeptide repeat-domain of the PAS10 protein of Saccharomyces cerevisiae is essential for binding the peroxisomal targeting signal-SKL. Biochem Biophys Res Commun 204(3):1016-22 SGD PMID 7980572
- ↑ 6.0 6.1 Gabaldon T, et al. (2006) Origin and evolution of the peroxisomal proteome. Biol Direct 1():8 SGD PMID 16556314
- ↑ 7.0 7.1 submitted by Toni Gabaldon on 2006-04-12
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