Difference between revisions of "YDR233C"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002641 YDR233C]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002641 YDR233C]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''RTN1 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''RTN1 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
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|nowrap| Chr IV:930354..929467
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|nowrap| Chr IV:930357..929470
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000002641
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000002641
 
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'''Description of YDR233C:''' ER membrane protein that interacts with exocyst subunit Sec6p and with Yip3p; also interacts with Sbh1p; null mutant has an altered (mostly cisternal) ER morphology; member of the RTNLA (reticulon-like A) subfamily<ref name='S000082473'>Geng J, et al. (2005) Saccharomyces cerevisiae Rab-GDI displacement factor ortholog Yip3p forms distinct complexes with the Ypt1 Rab GTPase and the reticulon Rtn1p. Eukaryot Cell 4(7):1166-74 {{SGDpaper|S000082473}} PMID 16002643</ref><ref name='S000115116'>De Craene JO, et al. (2006) Rtn1p is involved in structuring the cortical endoplasmic reticulum. Mol Biol Cell 17(7):3009-20 {{SGDpaper|S000115116}} PMID 16624861</ref><ref name='S000073531'>Oertle T, et al. (2003) A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family. FASEB J 17(10):1238-47 {{SGDpaper|S000073531}} PMID 12832288</ref><ref name='S000123819'>Feng D, et al. (2007) The transmembrane domain is sufficient for Sbh1p function, its association with the Sec61 complex, and interaction with Rtn1p. J Biol Chem 282(42):30618-28
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'''Description of YDR233C:''' Reticulon protein that stabilizes membrane curvature; interacts with Rtn2p, Yop1p, and Sey1p to maintain tubular ER morphology; involved in nuclear pore assembly; rtn1 rtn2 yop1 triple mutant shows loss of tubular ER; mutant overexpressing RTN1 shows increase in tubular ER; interacts with exocyst subunit Sec6p, with Yip3p, and with Sbh1p; similar to and more abundant than Rtn2p; member of the RTNLA (reticulon-like A) subfamily<ref name='S000129575'>Dawson TR, et al. (2009) ER membrane-bending proteins are necessary for de novo nuclear pore formation. J Cell Biol 184(5):659-75 {{SGDpaper|S000129575}} PMID 19273614</ref><ref name='S000115116'>De Craene JO, et al. (2006) Rtn1p is involved in structuring the cortical endoplasmic reticulum. Mol Biol Cell 17(7):3009-20 {{SGDpaper|S000115116}} PMID 16624861</ref><ref name='S000123819'>Feng D, et al. (2007) The transmembrane domain is sufficient for Sbh1p function, its association with the Sec61 complex, and interaction with Rtn1p. J Biol Chem 282(42):30618-28 {{SGDpaper|S000123819}} PMID 17699516</ref><ref name='S000082473'>Geng J, et al. (2005) Saccharomyces cerevisiae Rab-GDI displacement factor ortholog Yip3p forms distinct complexes with the Ypt1 Rab GTPase and the reticulon Rtn1p. Eukaryot Cell 4(7):1166-74 {{SGDpaper|S000082473}} PMID 16002643</ref><ref name='S000125669'>Hu J, et al. (2008) Membrane proteins of the endoplasmic reticulum induce high-curvature tubules. Science 319(5867):1247-50 {{SGDpaper|S000125669}} PMID 18309084</ref><ref name='S000131190'>Hu J, et al. (2009) A class of dynamin-like GTPases involved in the generation of the tubular ER network. Cell 138(3):549-61 {{SGDpaper|S000131190}} PMID 19665976</ref><ref name='S000073531'>Oertle T, et al. (2003) A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family. FASEB J 17(10):1238-47 {{SGDpaper|S000073531}} PMID 12832288</ref><ref name='S000126279'>Shibata Y, et al. (2008) The reticulon and dp1/yop1p proteins form immobile oligomers in the tubular endoplasmic reticulum. J Biol Chem 283(27):18892-904 {{SGDpaper|S000126279}} PMID 18442980</ref><ref name='S000114418'>Voeltz GK, et al. (2006) A class of membrane proteins shaping the tubular endoplasmic reticulum. Cell 124(3):573-86 {{SGDpaper|S000114418}} PMID 16469703</ref><ref name='S000145140'>West M, et al. (2011) A 3D analysis of yeast ER structure reveals how ER domains are organized by membrane curvature. J Cell Biol 193(2):333-46
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  {{SGDpaper|S000123819}} PMID 17699516</ref>
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  {{SGDpaper|S000145140}} PMID 21502358</ref>
 
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Latest revision as of 14:05, 11 May 2012

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Systematic name YDR233C
Gene name RTN1
Aliases
Feature type ORF, Verified
Coordinates Chr IV:930357..929470
Primary SGDID S000002641


Description of YDR233C: Reticulon protein that stabilizes membrane curvature; interacts with Rtn2p, Yop1p, and Sey1p to maintain tubular ER morphology; involved in nuclear pore assembly; rtn1 rtn2 yop1 triple mutant shows loss of tubular ER; mutant overexpressing RTN1 shows increase in tubular ER; interacts with exocyst subunit Sec6p, with Yip3p, and with Sbh1p; similar to and more abundant than Rtn2p; member of the RTNLA (reticulon-like A) subfamily[1][2][3][4][5][6][7][8][9][10]




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References

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  1. ↑ Dawson TR, et al. (2009) ER membrane-bending proteins are necessary for de novo nuclear pore formation. J Cell Biol 184(5):659-75 SGD PMID 19273614
  2. ↑ De Craene JO, et al. (2006) Rtn1p is involved in structuring the cortical endoplasmic reticulum. Mol Biol Cell 17(7):3009-20 SGD PMID 16624861
  3. ↑ Feng D, et al. (2007) The transmembrane domain is sufficient for Sbh1p function, its association with the Sec61 complex, and interaction with Rtn1p. J Biol Chem 282(42):30618-28 SGD PMID 17699516
  4. ↑ Geng J, et al. (2005) Saccharomyces cerevisiae Rab-GDI displacement factor ortholog Yip3p forms distinct complexes with the Ypt1 Rab GTPase and the reticulon Rtn1p. Eukaryot Cell 4(7):1166-74 SGD PMID 16002643
  5. ↑ Hu J, et al. (2008) Membrane proteins of the endoplasmic reticulum induce high-curvature tubules. Science 319(5867):1247-50 SGD PMID 18309084
  6. ↑ Hu J, et al. (2009) A class of dynamin-like GTPases involved in the generation of the tubular ER network. Cell 138(3):549-61 SGD PMID 19665976
  7. ↑ Oertle T, et al. (2003) A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family. FASEB J 17(10):1238-47 SGD PMID 12832288
  8. ↑ Shibata Y, et al. (2008) The reticulon and dp1/yop1p proteins form immobile oligomers in the tubular endoplasmic reticulum. J Biol Chem 283(27):18892-904 SGD PMID 18442980
  9. ↑ Voeltz GK, et al. (2006) A class of membrane proteins shaping the tubular endoplasmic reticulum. Cell 124(3):573-86 SGD PMID 16469703
  10. ↑ West M, et al. (2011) A 3D analysis of yeast ER structure reveals how ER domains are organized by membrane curvature. J Cell Biol 193(2):333-46 SGD PMID 21502358

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