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Systematic name YDR217C
Gene name RAD9
Feature type ORF, Verified
Coordinates Chr IV:903480..899551
Primary SGDID S000002625

Description of YDR217C: DNA damage-dependent checkpoint protein, required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; potential Cdc28p substrate[1][2]


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Alleles, Strains, and Phenotypes

Multiple Knockout Strains

Together with: DCC1, CTF8
Phenotype(s): Viable

ctf8 rad9 double deletion strain is defective in phosphorulation of Rad53p in responce to HU and MMS. [3] [4]

Together with: DCC1, CTF8
Phenotype(s): Viable

dcc1∆ rad9∆ double deletion strain is defective in phosphorylation of Rad53p and shows higher sensitivity to HU and MMS than WT and single mutant strains. [3] [4]

Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [2] [5]



See Help:References on how to add references

  1. Toh GW and Lowndes NF (2003) Role of the Saccharomyces cerevisiae Rad9 protein in sensing and responding to DNA damage. Biochem Soc Trans 31(Pt 1):242-6 SGD PMID 12546694
  2. 2.0 2.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415 Cite error: Invalid <ref> tag; name "S000074306" defined multiple times with different content
  3. 3.0 3.1 Pan X, et al. (2006) A DNA integrity network in the yeast Saccharomyces cerevisiae. Cell 124(5):1069-81 SGD PMID 16487579
  4. 4.0 4.1 submitted by Shin-ichiro Hiraga on 2006-06-20
  5. submitted by Jeff Ubersax on 2004-01-21

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