Difference between revisions of "YDR217C"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
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==Community Commentary==
 
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==References==
 
==References==
 
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Revision as of 08:17, 30 January 2007

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Systematic name YDR217C
Gene name RAD9
Aliases
Feature type ORF, Verified
Coordinates Chr IV:903476..899547


Description of YDR217C: DNA damage-dependent checkpoint protein, required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; potential Cdc28p substrate[1][2]




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Community Commentary

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Alleles, Strains, and Phenotypes

Multiple Knockout Strains

Together with: DCC1, CTF8
Phenotype(s): Viable

ctf8 rad9 double deletion strain is defective in phosphorulation of Rad53p in responce to HU and MMS. [3] [4]


Together with: DCC1, CTF8
Phenotype(s): Viable

dcc1∆ rad9∆ double deletion strain is defective in phosphorylation of Rad53p and shows higher sensitivity to HU and MMS than WT and single mutant strains. [3] [4]


Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [1] [5]


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References

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  1. 1.0 1.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
  2. Toh GW and Lowndes NF (2003) Role of the Saccharomyces cerevisiae Rad9 protein in sensing and responding to DNA damage. Biochem Soc Trans 31(Pt 1):242-6 SGD PMID 12546694
  3. 3.0 3.1 Pan X, et al. (2006) A DNA integrity network in the yeast Saccharomyces cerevisiae. Cell 124(5):1069-81 SGD PMID 16487579
  4. 4.0 4.1 submitted by Shin-ichiro Hiraga on 2006-06-20
  5. submitted by Jeff Ubersax on 2004-01-21

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