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Systematic name YDR146C
Gene name SWI5
Feature type ORF, Verified
Coordinates Chr IV:750742..748613
Primary SGDID S000002553

Description of YDR146C: Transcription factor that recruits the Mediator and Swi/Snf complexes; activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; required for expression of the HO gene controlling mating type switching; localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase[1][2][3][4][5][6][7]


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Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [7] [8]



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  1. Bhoite LT, et al. (2001) The Swi5 activator recruits the Mediator complex to the HO promoter without RNA polymerase II. Genes Dev 15(18):2457-69 SGD PMID 11562354
  2. Cosma MP, et al. (1999) Ordered recruitment of transcription and chromatin remodeling factors to a cell cycle- and developmentally regulated promoter. Cell 97(3):299-311 SGD PMID 10319811
  3. Dohrmann PR, et al. (1992) Parallel pathways of gene regulation: homologous regulators SWI5 and ACE2 differentially control transcription of HO and chitinase. Genes Dev 6(1):93-104 SGD PMID 1730413
  4. McBride HJ, et al. (1999) Distinct regions of the Swi5 and Ace2 transcription factors are required for specific gene activation. J Biol Chem 274(30):21029-36 SGD PMID 10409653
  5. Moll T, et al. (1991) The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SWI5. Cell 66(4):743-58 SGD PMID 1652372
  6. Stern M, et al. (1984) Five SWI genes are required for expression of the HO gene in yeast. J Mol Biol 178(4):853-68 SGD PMID 6436497
  7. 7.0 7.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415 Cite error: Invalid <ref> tag; name "S000074306" defined multiple times with different content
  8. submitted by Jeff Ubersax on 2004-01-21

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