Difference between revisions of "YDR138W"

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==Community Commentary==
 
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==References==
 
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Revision as of 08:17, 30 January 2007

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Systematic name YDR138W
Gene name HPR1
Aliases TRF1
Feature type ORF, Verified
Coordinates Chr IV:730575..732833


Description of YDR138W: Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p[1][2][3][4][5][6][7][8]




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Community Commentary

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References

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  1. Askree SH, et al. (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63 SGD PMID 15161972
  2. Jimeno S, et al. (2002) The yeast THO complex and mRNA export factors link RNA metabolism with transcription and genome instability. EMBO J 21(13):3526-35 SGD PMID 12093753
  3. Merker RJ and Klein HL (2002) hpr1Delta affects ribosomal DNA recombination and cell life span in Saccharomyces cerevisiae. Mol Cell Biol 22(2):421-9 SGD PMID 11756539
  4. Chavez S, et al. (2001) Hpr1 is preferentially required for transcription of either long or G+C-rich DNA sequences in Saccharomyces cerevisiae. Mol Cell Biol 21(20):7054-64 SGD PMID 11564888
  5. Chavez S and Aguilera A (1997) The yeast HPR1 gene has a functional role in transcriptional elongation that uncovers a novel source of genome instability. Genes Dev 11(24):3459-70 SGD PMID 9407037
  6. Chavez S, et al. (2000) A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae. EMBO J 19(21):5824-34 SGD PMID 11060033
  7. Aguilera A and Klein HL (1990) HPR1, a novel yeast gene that prevents intrachromosomal excision recombination, shows carboxy-terminal homology to the Saccharomyces cerevisiae TOP1 gene. Mol Cell Biol 10(4):1439-51 SGD PMID 2181275
  8. Chang M, et al. (1999) A complex containing RNA polymerase II, Paf1p, Cdc73p, Hpr1p, and Ccr4p plays a role in protein kinase C signaling. Mol Cell Biol 19(2):1056-67 SGD PMID 9891041

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