Difference between revisions of "YDR121W"
SGDwikiBot (talk | contribs) (Automated import of articles) |
SGDwikiBot (talk | contribs) (Automated import of articles) |
||
| (12 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
<!-- PLEASE DO NOT EDIT HERE. USE THE SECTION EDIT LINKS ON THE RIGHT MARGIN--> | <!-- PLEASE DO NOT EDIT HERE. USE THE SECTION EDIT LINKS ON THE RIGHT MARGIN--> | ||
{{PageTop}} | {{PageTop}} | ||
| + | <protect> | ||
{|{{Prettytable}} align = 'right' width = '200px' | {|{{Prettytable}} align = 'right' width = '200px' | ||
|- | |- | ||
| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002528 YDR121W] |
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''DPB4 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''DPB4 '' | ||
| Line 12: | Line 13: | ||
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr IV: | + | |nowrap| Chr IV:693585..694175 |
|- | |- | ||
| − | | | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000002528 |
|} | |} | ||
<br> | <br> | ||
| − | '''Description of | + | '''Description of YDR121W:''' Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization<ref name='S000141383'>Aksenova A, et al. (2010) Mismatch Repair-Independent Increase in Spontaneous Mutagenesis in Yeast Lacking Non-Essential Subunits of DNA Polymerase epsilon. PLoS Genet 6(11):e1001209 {{SGDpaper|S000141383}} PMID 21124948</ref><ref name='S000122597'>Dang W, et al. (2007) The Dpb4 Subunit of ISW2 Is Anchored to Extranucleosomal DNA. J Biol Chem 282(27):19418-25 {{SGDpaper|S000122597}} PMID 17491017</ref><ref name='S000050160'>Dua R, et al. (2000) Subunit interactions within the Saccharomyces cerevisiae DNA polymerase epsilon (pol epsilon ) complex. Demonstration of a dimeric pol epsilon. J Biol Chem 275(37):28816-25 {{SGDpaper|S000050160}} PMID 10878005</ref><ref name='S000075426'>Iida T and Araki H (2004) Noncompetitive counteractions of DNA polymerase epsilon and ISW2/yCHRAC for epigenetic inheritance of telomere position effect in Saccharomyces cerevisiae. Mol Cell Biol 24(1):217-27 {{SGDpaper|S000075426}} PMID 14673157</ref><ref name='S000054633'>Li Y, et al. (2000) Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon. J Biol Chem 275(30):23247-52 {{SGDpaper|S000054633}} PMID 10801849</ref><ref name='S000056444'>Ohya T, et al. (2000) Structure and function of the fourth subunit (Dpb4p) of DNA polymerase epsilon in Saccharomyces cerevisiae. Nucleic Acids Res 28(20):3846-52 |
| − | {{SGDpaper| | + | {{SGDpaper|S000056444}} PMID 11024162</ref> |
<br> | <br> | ||
<br> | <br> | ||
<br> | <br> | ||
<br> | <br> | ||
| − | + | <br> | |
| + | </protect> | ||
__TOC__ | __TOC__ | ||
==Community Commentary== | ==Community Commentary== | ||
{{CommentaryHelp}} | {{CommentaryHelp}} | ||
| + | |||
| + | |||
| + | |||
| + | <!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation --> | ||
| + | <!-- | ||
| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
| + | --> | ||
| + | |||
| + | |||
| + | |||
| + | <protect> | ||
==References== | ==References== | ||
<!-- REFERENCES ARE AUTOMATICALLY GENERATED. PLEASE DON'T EDIT THIS SECTION--> | <!-- REFERENCES ARE AUTOMATICALLY GENERATED. PLEASE DON'T EDIT THIS SECTION--> | ||
{{RefHelp}} | {{RefHelp}} | ||
| + | </protect> | ||
Latest revision as of 14:05, 1 October 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YDR121W |
| Gene name | DPB4 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:693585..694175 |
| Primary SGDID | S000002528 |
Description of YDR121W: Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization[1][2][3][4][5][6]
</protect>
Contents
Community Commentary
About Community Commentary. Please share your knowledge!
<protect>
References
See Help:References on how to add references
- ↑ Aksenova A, et al. (2010) Mismatch Repair-Independent Increase in Spontaneous Mutagenesis in Yeast Lacking Non-Essential Subunits of DNA Polymerase epsilon. PLoS Genet 6(11):e1001209 SGD PMID 21124948
- ↑ Dang W, et al. (2007) The Dpb4 Subunit of ISW2 Is Anchored to Extranucleosomal DNA. J Biol Chem 282(27):19418-25 SGD PMID 17491017
- ↑ Dua R, et al. (2000) Subunit interactions within the Saccharomyces cerevisiae DNA polymerase epsilon (pol epsilon ) complex. Demonstration of a dimeric pol epsilon. J Biol Chem 275(37):28816-25 SGD PMID 10878005
- ↑ Iida T and Araki H (2004) Noncompetitive counteractions of DNA polymerase epsilon and ISW2/yCHRAC for epigenetic inheritance of telomere position effect in Saccharomyces cerevisiae. Mol Cell Biol 24(1):217-27 SGD PMID 14673157
- ↑ Li Y, et al. (2000) Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon. J Biol Chem 275(30):23247-52 SGD PMID 10801849
- ↑ Ohya T, et al. (2000) Structure and function of the fourth subunit (Dpb4p) of DNA polymerase epsilon in Saccharomyces cerevisiae. Nucleic Acids Res 28(20):3846-52 SGD PMID 11024162
See Help:Categories on how to add the wiki page for this gene to a Category </protect>
