Difference between revisions of "YDR103W"
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| − | '''Description of YDR103W:''' Pheromone-response scaffold protein; binds Ste11p, Ste7p, and Fus3p kinases, forming a MAPK cascade complex that interacts with the plasma membrane and Ste4p-Ste18p; allosteric activator of Fus3p that facilitates Ste7p-mediated activation<ref name='S000048143'>Choi KY, et al. (1999) Characterization of Fus3 localization: active Fus3 localizes in complexes of varying size and specific activity. Mol Biol Cell 10(5):1553-68 {{SGDpaper|S000048143}} PMID 10233162</ref><ref name=' | + | '''Description of YDR103W:''' Pheromone-response scaffold protein; binds Ste11p, Ste7p, and Fus3p kinases, forming a MAPK cascade complex that interacts with the plasma membrane and Ste4p-Ste18p; allosteric activator of Fus3p that facilitates Ste7p-mediated activation<ref name='S000048143'>Choi KY, et al. (1999) Characterization of Fus3 localization: active Fus3 localizes in complexes of varying size and specific activity. Mol Biol Cell 10(5):1553-68 {{SGDpaper|S000048143}} PMID 10233162</ref><ref name='S000120550'>Garrenton LS, et al. (2006) Function of the MAPK scaffold protein, Ste5, requires a cryptic PH domain. Genes Dev 20(14):1946-58 {{SGDpaper|S000120550}} PMID 16847350</ref><ref name='S000129764'>Good M, et al. (2009) The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation. Cell 136(6):1085-97 {{SGDpaper|S000129764}} PMID 19303851</ref><ref name='S000126703'>Hao N, et al. (2008) Regulation of cell signaling dynamics by the protein kinase-scaffold Ste5. Mol Cell 30(5):649-56 {{SGDpaper|S000126703}} PMID 18538663</ref><ref name='S000053549'>Kranz JE, et al. (1994) The MAP kinase Fus3 associates with and phosphorylates the upstream signaling component Ste5. Genes Dev 8(3):313-27 {{SGDpaper|S000053549}} PMID 8314085</ref><ref name='S000050302'>Printen JA and Sprague GF Jr (1994) Protein-protein interactions in the yeast pheromone response pathway: Ste5p interacts with all members of the MAP kinase cascade. Genetics 138(3):609-19 {{SGDpaper|S000050302}} PMID 7851759</ref><ref name='S000086905'>Winters MJ, et al. (2005) A membrane binding domain in the ste5 scaffold synergizes with gbetagamma binding to control localization and signaling in pheromone response. Mol Cell 20(1):21-32 |
| − | {{SGDpaper| | + | {{SGDpaper|S000086905}} PMID 16209942</ref> |
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Revision as of 14:05, 25 February 2010
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| Systematic name | YDR103W |
| Gene name | STE5 |
| Aliases | HMD3, NUL3 |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:658348..661101 |
| Primary SGDID | S000002510 |
Description of YDR103W: Pheromone-response scaffold protein; binds Ste11p, Ste7p, and Fus3p kinases, forming a MAPK cascade complex that interacts with the plasma membrane and Ste4p-Ste18p; allosteric activator of Fus3p that facilitates Ste7p-mediated activation[1][2][3][4][5][6][7]
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References
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- ↑ Choi KY, et al. (1999) Characterization of Fus3 localization: active Fus3 localizes in complexes of varying size and specific activity. Mol Biol Cell 10(5):1553-68 SGD PMID 10233162
- ↑ Garrenton LS, et al. (2006) Function of the MAPK scaffold protein, Ste5, requires a cryptic PH domain. Genes Dev 20(14):1946-58 SGD PMID 16847350
- ↑ Good M, et al. (2009) The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation. Cell 136(6):1085-97 SGD PMID 19303851
- ↑ Hao N, et al. (2008) Regulation of cell signaling dynamics by the protein kinase-scaffold Ste5. Mol Cell 30(5):649-56 SGD PMID 18538663
- ↑ Kranz JE, et al. (1994) The MAP kinase Fus3 associates with and phosphorylates the upstream signaling component Ste5. Genes Dev 8(3):313-27 SGD PMID 8314085
- ↑ Printen JA and Sprague GF Jr (1994) Protein-protein interactions in the yeast pheromone response pathway: Ste5p interacts with all members of the MAP kinase cascade. Genetics 138(3):609-19 SGD PMID 7851759
- ↑ Winters MJ, et al. (2005) A membrane binding domain in the ste5 scaffold synergizes with gbetagamma binding to control localization and signaling in pheromone response. Mol Cell 20(1):21-32 SGD PMID 16209942
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