YDR097C
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| Systematic name | YDR097C |
| Gene name | MSH6 |
| Aliases | PMS3 |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:643835..640107 |
| Primary SGDID | S000002504 |
Description of YDR097C: Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; potentially phosphorylated by Cdc28p[1][2][3]
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [1] [4]
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References
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- ↑ 1.0 1.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
- ↑ Bowers J, et al. (1999) A mutation in the MSH6 subunit of the Saccharomyces cerevisiae MSH2-MSH6 complex disrupts mismatch recognition. J Biol Chem 274(23):16115-25 SGD PMID 10347163
- ↑ Marsischky GT, et al. (1996) Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair. Genes Dev 10(4):407-20 SGD PMID 8600025
- ↑ submitted by Jeff Ubersax on 2004-01-21
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