Difference between revisions of "YDR096W"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002503 YDR096W]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002503 YDR096W]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''GIS1 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''GIS1 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr IV:637137..639821
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|nowrap| Chr IV:637139..639823
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000002503
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000002503
 
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'''Description of YDR096W:''' JmjC domain-containing histone demethylase; transcription factor involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1<ref name='S000046845'>Jang YK, et al. (1999) RPH1 and GIS1 are damage-responsive repressors of PHR1. Mol Cell Biol 19(11):7630-8 {{SGDpaper|S000046845}} PMID 10523651</ref><ref name='S000051003'>Pedruzzi I, et al. (2000) Saccharomyces cerevisiae Ras/cAMP pathway controls post-diauxic shift element-dependent transcription through the zinc finger protein Gis1. EMBO J 19(11):2569-79 {{SGDpaper|S000051003}} PMID 10835355</ref><ref name='S000062114'>Balciunas D and Ronne H (1999) Yeast genes GIS1-4: multicopy suppressors of the Gal- phenotype of snf1 mig1 srb8/10/11 cells. Mol Gen Genet 262(4-5):589-99 {{SGDpaper|S000062114}} PMID 10628841</ref><ref name='S000073858'>Oshiro J, et al. (2003) Regulation of the yeast DPP1-encoded diacylglycerol pyrophosphate phosphatase by transcription factor Gis1p. J Biol Chem 278(34):31495-503 {{SGDpaper|S000073858}} PMID 12799368</ref><ref name='S000121921'>Tu S, et al. (2007) Identification of histone demethylases in Saccharomyces cerevisiae. J Biol Chem 282(19):14262-71
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'''Description of YDR096W:''' JmjC domain-containing histone demethylase and transcription factor; involved in expression of genes during nutrient limitation; negatively regulates DPP1 and PHR1; activity is modulated by limited proteasome-mediated proteolysis; has a JmjC and a JmjN domain in the N-terminal region that interact, promoting Gis1p stability and proper transcriptional activity; contains transactivating domains TAD1 and TAD2 downstream of the Jmj domains and a C-terminal DNA binding domain<ref name='S000062114'>Balciunas D and Ronne H (1999) Yeast genes GIS1-4: multicopy suppressors of the Gal- phenotype of snf1 mig1 srb8/10/11 cells. Mol Gen Genet 262(4-5):589-99 {{SGDpaper|S000062114}} PMID 10628841</ref><ref name='S000046845'>Jang YK, et al. (1999) RPH1 and GIS1 are damage-responsive repressors of PHR1. Mol Cell Biol 19(11):7630-8 {{SGDpaper|S000046845}} PMID 10523651</ref><ref name='S000073858'>Oshiro J, et al. (2003) Regulation of the yeast DPP1-encoded diacylglycerol pyrophosphate phosphatase by transcription factor Gis1p. J Biol Chem 278(34):31495-503 {{SGDpaper|S000073858}} PMID 12799368</ref><ref name='S000051003'>Pedruzzi I, et al. (2000) Saccharomyces cerevisiae Ras/cAMP pathway controls post-diauxic shift element-dependent transcription through the zinc finger protein Gis1. EMBO J 19(11):2569-79 {{SGDpaper|S000051003}} PMID 10835355</ref><ref name='S000145832'>Quan Z, et al. (2011) JmjN interacts with JmjC to ensure selective degradation of Gis1 by the proteasome. Microbiology () {{SGDpaper|S000145832}} PMID 21680636</ref><ref name='S000121921'>Tu S, et al. (2007) Identification of histone demethylases in Saccharomyces cerevisiae. J Biol Chem 282(19):14262-71 {{SGDpaper|S000121921}} PMID 17369256</ref><ref name='S000134382'>Zhang N and Oliver SG (2010) The transcription activity of Gis1 is negatively modulated by proteasome-mediated limited proteolysis. J Biol Chem 285(9):6465-76
  {{SGDpaper|S000121921}} PMID 17369256</ref>
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  {{SGDpaper|S000134382}} PMID 20022953</ref>
 
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Latest revision as of 07:45, 23 January 2012

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Systematic name YDR096W
Gene name GIS1
Aliases
Feature type ORF, Verified
Coordinates Chr IV:637139..639823
Primary SGDID S000002503


Description of YDR096W: JmjC domain-containing histone demethylase and transcription factor; involved in expression of genes during nutrient limitation; negatively regulates DPP1 and PHR1; activity is modulated by limited proteasome-mediated proteolysis; has a JmjC and a JmjN domain in the N-terminal region that interact, promoting Gis1p stability and proper transcriptional activity; contains transactivating domains TAD1 and TAD2 downstream of the Jmj domains and a C-terminal DNA binding domain[1][2][3][4][5][6][7]




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References

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  1. Balciunas D and Ronne H (1999) Yeast genes GIS1-4: multicopy suppressors of the Gal- phenotype of snf1 mig1 srb8/10/11 cells. Mol Gen Genet 262(4-5):589-99 SGD PMID 10628841
  2. Jang YK, et al. (1999) RPH1 and GIS1 are damage-responsive repressors of PHR1. Mol Cell Biol 19(11):7630-8 SGD PMID 10523651
  3. Oshiro J, et al. (2003) Regulation of the yeast DPP1-encoded diacylglycerol pyrophosphate phosphatase by transcription factor Gis1p. J Biol Chem 278(34):31495-503 SGD PMID 12799368
  4. Pedruzzi I, et al. (2000) Saccharomyces cerevisiae Ras/cAMP pathway controls post-diauxic shift element-dependent transcription through the zinc finger protein Gis1. EMBO J 19(11):2569-79 SGD PMID 10835355
  5. Quan Z, et al. (2011) JmjN interacts with JmjC to ensure selective degradation of Gis1 by the proteasome. Microbiology () SGD PMID 21680636
  6. Tu S, et al. (2007) Identification of histone demethylases in Saccharomyces cerevisiae. J Biol Chem 282(19):14262-71 SGD PMID 17369256
  7. Zhang N and Oliver SG (2010) The transcription activity of Gis1 is negatively modulated by proteasome-mediated limited proteolysis. J Biol Chem 285(9):6465-76 SGD PMID 20022953

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