YDR085C

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Systematic name YDR085C
Gene name AFR1
Aliases
Feature type ORF, Verified
Coordinates Chr IV:616148..614286
Primary SGDID S000002492


Description of YDR085C: Alpha-factor pheromone receptor regulator, negatively regulates pheromone receptor signaling; required for normal mating projection (shmoo) formation; required for Spa2p to recruit Mpk1p to shmoo tip during mating; interacts with Cdc12p[1][2][3][4]




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References

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  1. DeMattei CR, et al. (2000) Point mutations identify a conserved region of the saccharomyces cerevisiae AFR1 gene that is essential for both the pheromone signaling and morphogenesis functions. Genetics 155(1):43-55 SGD PMID 10790383
  2. Konopka JB (1993) AFR1 acts in conjunction with the alpha-factor receptor to promote morphogenesis and adaptation. Mol Cell Biol 13(11):6876-88 SGD PMID 8413281
  3. Giot L and Konopka JB (1997) Functional analysis of the interaction between Afr1p and the Cdc12p septin, two proteins involved in pheromone-induced morphogenesis. Mol Biol Cell 8(6):987-98 SGD PMID 9201710
  4. Changwei Z, et al. (2007) Afr1p has a role in regulating the localization of Mpk1p at the shmoo tip in Saccharomyces cerevisiae. FEBS Lett 581(14):2670-4 SGD PMID 17509572

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