Difference between revisions of "YDR081C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002488 YDR081C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''PDC2 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''PDC2 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr IV: | + | |nowrap| Chr IV:610081..607304 |
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| + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000002488 | ||
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<br> | <br> | ||
| − | '''Description of | + | '''Description of YDR081C:''' Transcription factor for thiamine-regulated genes; required for expression of the two isoforms of pyruvate decarboxylase (PDC1 and PDC5) along with thiamine biosynthetic genes; binds a DNA sequence in the PDC5 promoter; mutant fails to grow on 2% glucose and thus is scored as inviable under standard conditions<ref name='S000050008'>Hohmann S (1993) Characterisation of PDC2, a gene necessary for high level expression of pyruvate decarboxylase structural genes in Saccharomyces cerevisiae. Mol Gen Genet 241(5-6):657-66 {{SGDpaper|S000050008}} PMID 8264540</ref><ref name='S000046055'>Hohmann S and Meacock PA (1998) Thiamin metabolism and thiamin diphosphate-dependent enzymes in the yeast Saccharomyces cerevisiae: genetic regulation. Biochim Biophys Acta 1385(2):201-19 {{SGDpaper|S000046055}} PMID 9655908</ref><ref name='S000117265'>Mojzita D and Hohmann S (2006) Pdc2 coordinates expression of the THI regulon in the yeast Saccharomyces cerevisiae. Mol Genet Genomics 276(2):147-61 {{SGDpaper|S000117265}} PMID 16850348</ref><ref name='S000128371'>Nosaka K, et al. (2008) Thiamin-dependent transactivation activity of PDC2 in Saccharomyces cerevisiae. FEBS Lett 582(29):3991-6 {{SGDpaper|S000128371}} PMID 19013460</ref><ref name='S000148779'>Nosaka K, et al. (2012) Facilitated recruitment of Pdc2p, a yeast transcriptional activator, in response to thiamin starvation.LID - 10.1111/j.1574-6968.2012.02543.x [doi] FEMS Microbiol Lett () {{SGDpaper|S000148779}} PMID 22404710</ref><ref name='S000147201'>Raghuram V, et al. (1994) PDC2, a yeast gene essential for synthesis of pyruvate decarboxylase, encodes a novel transcription factor J Genet 73():17-32 {{SGDpaper|S000147201}} PMID </ref><ref name='S000042760'>Velmurugan S, et al. (1997) Suppression of pdc2 regulating pyruvate decarboxylase synthesis in yeast. Genetics 145(3):587-94 |
{{SGDpaper|S000042760}} PMID 9055069</ref> | {{SGDpaper|S000042760}} PMID 9055069</ref> | ||
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J Biol Chem 278(5):3265-74</ref> | J Biol Chem 278(5):3265-74</ref> | ||
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Latest revision as of 14:05, 26 March 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YDR081C |
| Gene name | PDC2 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:610081..607304 |
| Primary SGDID | S000002488 |
Description of YDR081C: Transcription factor for thiamine-regulated genes; required for expression of the two isoforms of pyruvate decarboxylase (PDC1 and PDC5) along with thiamine biosynthetic genes; binds a DNA sequence in the PDC5 promoter; mutant fails to grow on 2% glucose and thus is scored as inviable under standard conditions[1][2][3][4][5][6][7]
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References
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- ↑ Hohmann S (1993) Characterisation of PDC2, a gene necessary for high level expression of pyruvate decarboxylase structural genes in Saccharomyces cerevisiae. Mol Gen Genet 241(5-6):657-66 SGD PMID 8264540
- ↑ Hohmann S and Meacock PA (1998) Thiamin metabolism and thiamin diphosphate-dependent enzymes in the yeast Saccharomyces cerevisiae: genetic regulation. Biochim Biophys Acta 1385(2):201-19 SGD PMID 9655908
- ↑ Mojzita D and Hohmann S (2006) Pdc2 coordinates expression of the THI regulon in the yeast Saccharomyces cerevisiae. Mol Genet Genomics 276(2):147-61 SGD PMID 16850348
- ↑ Nosaka K, et al. (2008) Thiamin-dependent transactivation activity of PDC2 in Saccharomyces cerevisiae. FEBS Lett 582(29):3991-6 SGD PMID 19013460
- ↑ Nosaka K, et al. (2012) Facilitated recruitment of Pdc2p, a yeast transcriptional activator, in response to thiamin starvation.LID - 10.1111/j.1574-6968.2012.02543.x [doi] FEMS Microbiol Lett () SGD PMID 22404710
- ↑ Raghuram V, et al. (1994) PDC2, a yeast gene essential for synthesis of pyruvate decarboxylase, encodes a novel transcription factor J Genet 73():17-32 SGD PMID
- ↑ Velmurugan S, et al. (1997) Suppression of pdc2 regulating pyruvate decarboxylase synthesis in yeast. Genetics 145(3):587-94 SGD PMID 9055069
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