Difference between revisions of "YDR052C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002459 YDR052C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''DBF4 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''DBF4 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr IV: | + | |nowrap| Chr IV:560625..558511 |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000002459 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000002459 | ||
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| − | '''Description of YDR052C:''' Regulatory subunit of Cdc7p-Dbf4p kinase complex, required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated<ref name=' | + | '''Description of YDR052C:''' Regulatory subunit of Cdc7p-Dbf4p kinase complex, required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated<ref name='S000048592'>Cheng L, et al. (1999) Cell cycle regulation of DNA replication initiator factor Dbf4p. Mol Cell Biol 19(6):4270-8 {{SGDpaper|S000048592}} PMID 10330168</ref><ref name='S000051467'>Lei M, et al. (1997) Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis. Genes Dev 11(24):3365-74 |
| − | {{SGDpaper| | + | {{SGDpaper|S000051467}} PMID 9407029</ref> |
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Latest revision as of 07:45, 23 January 2012
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| Systematic name | YDR052C |
| Gene name | DBF4 |
| Aliases | DNA52, LSD7 |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:560625..558511 |
| Primary SGDID | S000002459 |
Description of YDR052C: Regulatory subunit of Cdc7p-Dbf4p kinase complex, required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated[1][2]
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [3] [4]
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References
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- ↑ Cheng L, et al. (1999) Cell cycle regulation of DNA replication initiator factor Dbf4p. Mol Cell Biol 19(6):4270-8 SGD PMID 10330168
- ↑ Lei M, et al. (1997) Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis. Genes Dev 11(24):3365-74 SGD PMID 9407029
- ↑ Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
- ↑ submitted by Jeff Ubersax on 2004-01-21
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