Difference between revisions of "YDR049W"
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| − | '''Description of YDR049W:''' | + | '''Description of YDR049W:''' Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans<ref name='S000058122'>Bohm S, et al. (1997) Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins. Nucleic Acids Res 25(12):2464-9 {{SGDpaper|S000058122}} PMID 9171100</ref><ref name='S000140158'>Heo JM, et al. (2010) A stress-responsive system for mitochondrial protein degradation. Mol Cell 40(3):465-80 {{SGDpaper|S000140158}} PMID 21070972</ref><ref name='S000145091'>Tran JR, et al. (2011) A Cdc48p-associated factor modulates endoplasmic reticulum-associated degradation, cell stress, and ubiquitinated protein homeostasis. J Biol Chem 286(7):5744-55 |
| − | {{SGDpaper| | + | {{SGDpaper|S000145091}} PMID 21148305</ref> |
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Revision as of 14:05, 19 May 2011
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| Systematic name | YDR049W |
| Gene name | VMS1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:553254..555152 |
| Primary SGDID | S000002456 |
Description of YDR049W: Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans[1][2][3]
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References
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- ↑ Bohm S, et al. (1997) Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins. Nucleic Acids Res 25(12):2464-9 SGD PMID 9171100
- ↑ Heo JM, et al. (2010) A stress-responsive system for mitochondrial protein degradation. Mol Cell 40(3):465-80 SGD PMID 21070972
- ↑ Tran JR, et al. (2011) A Cdc48p-associated factor modulates endoplasmic reticulum-associated degradation, cell stress, and ubiquitinated protein homeostasis. J Biol Chem 286(7):5744-55 SGD PMID 21148305
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