Difference between revisions of "YDR028C"

Latest revision as of 07:45, 23 January 2012

Share your knowledge...Edit this entry! <protect>

Systematic name	YDR028C
Gene name	REG1
Aliases	HEX2, PZF240, SPP43, SRN1
Feature type	ORF, Verified
Coordinates	Chr IV:500879..497835
Primary SGDID	S000002435

Description of YDR028C: Regulatory subunit of type 1 protein phosphatase Glc7p, involved in negative regulation of glucose-repressible genes^[1]^[2]^[3]

</protect>

Community Commentary

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Alleles, Strains, and Phenotypes

Complete Deletion

Allele: reg1::URA3

Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4569
Together with: SIP1, GAL83, SIP2, MUC1
Phenotype(s): Loss of function (Null)

reg1 mutants are consitutively filamentous (filamentous even in the presence of glucose, unlike wild-type, which filaments on media lacking glucose). ^[4] ^[5]

Allele: reg1::URA3

Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4569
Together with: SIP1, GAL83, SIP2, MUC1
Phenotype(s): Loss of function (Null)

reg1 mutants display a constitutive invasive phenotype (they invade better than wild-type on medium containing high glucose (2%), but about the same as wild-type in limiting glucose (0.1%)). ^[4] ^[5]

Allele: reg1::URA3

Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4569
Together with: SIP1, GAL83, SIP2, MUC1
Phenotype(s): Loss of function (Null)

reg1 mutants are consitutively filamentous (filamentous even in the presence of glucose, unlike wild-type, which filaments on media lacking glucose). ^[4] ^[5]

Allele: reg1::URA3

Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4569
Together with: SIP1, GAL83, SIP2, MUC1
Phenotype(s): Loss of function (Null)

reg1 mutants display a constitutive invasive phenotype (they invade better than wild-type on medium containing high glucose (2%), but about the same as wild-type in limiting glucose (0.1%)). ^[4] ^[5]

Allele: reg1::URA3

Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4462
Together with: SNF1
Phenotype(s): Loss of function (Null)

reg1 mutants invade better than wild-type. ^[6] ^[5]

Multiple Knockout Strains

Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4469
Together with: SIP1, GAL83, SIP2, MUC1
Phenotype(s): Loss of function (Null)

Deletion of FLO11/MUC1 suppresses reg1's constitutive invasion phenotype, but not its constitutive filamentous phenotype. ^[4] ^[5]

Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4571
Together with: SIP1, GAL83, SIP2, MUC1
Phenotype(s): Loss of function (Null)

Deletion of GAL83 suppresses reg1's constitutive adherance to plastic (adherance in high glucose (2%)). ^[4] ^[5]

Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4633
Together with: SIP1, GAL83, SIP2, MUC1
Phenotype(s): Loss of function (Null)

Deletion of both SIP2 and GAL83 in a reg1 mutant suppresses its constitutive filamentous phenotype. ^[4] ^[5]

Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4571
Together with: SIP1, GAL83, SIP2, MUC1
Phenotype(s): Loss of function (Null)

Deletion of GAL83 suppresses reg1's constitutive adherance to plastic (adherance in high glucose (2%)). ^[4] ^[5]

Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4469
Together with: SIP1, GAL83, SIP2, MUC1
Phenotype(s): Loss of function (Null)

Deletion of FLO11/MUC1 suppresses reg1's constitutive invasion phenotype, but not its constitutive filamentous phenotype. ^[4] ^[5]

Strain Background: Sigma1278b (Sigma 2000 series)
Genotype: MCY4633
Together with: SIP1, GAL83, SIP2, MUC1
Phenotype(s): Loss of function (Null)

Deletion of both SIP2 and GAL83 in a reg1 mutant suppresses its constitutive filamentous phenotype. ^[4] ^[5]

Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4618
Together with: SIP1, GAL83, SIP2, MUC1
Phenotype(s): Loss of function (Null), FLO11/MUC1 promoter substituted with S.p.Adh+ promoter

Deletion of REG1 in cells where FLO11/MUC1 expression is clamped (by substitution of the FLO11 promoter with the S.pombe Adh+promoter) causes an increase in invasion. ^[4] ^[5]

Strain Background: Sigma1278b
Genotype: MCY4461
Together with: SNF1
Phenotype(s): Loss of function (Null)

Deletion of SNF1 suppresses the hyperinvasive phenotype of reg1. ^[6] ^[5]

Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4618
Together with: SIP1, GAL83, SIP2, MUC1
Phenotype(s): Loss of function (Null), FLO11/MUC1 promoter substituted with S.p.Adh+ promoter

Deletion of REG1 in cells where FLO11/MUC1 expression is clamped (by substitution of the FLO11 promoter with the S.pombe Adh+promoter) causes an increase in invasion. ^[4] ^[5]

References

See Help:References on how to add references

↑ Frederick DL and Tatchell K (1996) The REG2 gene of Saccharomyces cerevisiae encodes a type 1 protein phosphatase-binding protein that functions with Reg1p and the Snf1 protein kinase to regulate growth. Mol Cell Biol 16(6):2922-31 SGD PMID 8649403
↑ Niederacher D and Entian KD (1987) Isolation and characterization of the regulatory HEX2 gene necessary for glucose repression in yeast. Mol Gen Genet 206(3):505-9 SGD PMID 3035346
↑ Tu J and Carlson M (1995) REG1 binds to protein phosphatase type 1 and regulates glucose repression in Saccharomyces cerevisiae. EMBO J 14(23):5939-46 SGD PMID 8846786
↑ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 SGD PMID 12556493
↑ ^5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 ^5.12 ^5.13 submitted by Valmik K. Vyas on 2003-03-27
↑ ^6.0 ^6.1 Kuchin S, et al. (2002) Snf1 protein kinase and the repressors Nrg1 and Nrg2 regulate FLO11, haploid invasive growth, and diploid pseudohyphal differentiation. Mol Cell Biol 22(12):3994-4000 SGD PMID 12024013

See Help:Categories on how to add the wiki page for this gene to a Category </protect>

[S000055740-1] Frederick DL and Tatchell K (1996) The REG2 gene of Saccharomyces cerevisiae encodes a type 1 protein phosphatase-binding protein that functions with Reg1p and the Snf1 protein kinase to regulate growth. Mol Cell Biol 16(6):2922-31 SGD PMID 8649403

[S000040393-2] Niederacher D and Entian KD (1987) Isolation and characterization of the regulatory HEX2 gene necessary for glucose repression in yeast. Mol Gen Genet 206(3):505-9 SGD PMID 3035346

[S000046186-3] Tu J and Carlson M (1995) REG1 binds to protein phosphatase type 1 and regulates glucose repression in Saccharomyces cerevisiae. EMBO J 14(23):5939-46 SGD PMID 8846786

[S000072732-4] 4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 SGD PMID 12556493

[CAset6176-2003-03-27-5] 5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 ^5.12 ^5.13 submitted by Valmik K. Vyas on 2003-03-27

[S000070028-6] 6.0 ^6.1 Kuchin S, et al. (2002) Snf1 protein kinase and the repressors Nrg1 and Nrg2 regulate FLO11, haploid invasive growth, and diploid pseudohyphal differentiation. Mol Cell Biol 22(12):3994-4000 SGD PMID 12024013

[1]

[2]

[3]

[4]

[5]

[6]

@@ Line 1: / Line 1: @@
 <!-- PLEASE DO NOT EDIT HERE. USE THE SECTION EDIT LINKS ON THE RIGHT MARGIN-->
 {{PageTop}}
+<protect>
 {|{{Prettytable}} align = 'right' width = '200px'
 |-
-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YDR028C YDR028C]
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002435 YDR028C]
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''         ||''REG1 ''
@@ Line 12: / Line 13: @@
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
-|nowrap| Chr IV:500876..497832
+|nowrap| Chr IV:500879..497835
 |-
-|colspan = '3'|{{Don'tEditThisBox}}
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''           || S000002435
 |}
 <br>
-'''Description of {{PAGENAME}}:''' Regulatory subunit of type 1 protein phosphatase Glc7p, involved in negative regulation of glucose-repressible genes<ref name='S000055740'>Frederick DL and Tatchell K (1996) The REG2 gene of Saccharomyces cerevisiae encodes a type 1 protein phosphatase-binding protein that functions with Reg1p and the Snf1 protein kinase to regulate growth. Mol Cell Biol 16(6):2922-31 {{SGDpaper|S000055740}} PMID 8649403</ref><ref name='S000046186'>Tu J and Carlson M (1995) REG1 binds to protein phosphatase type 1 and regulates glucose repression in Saccharomyces cerevisiae. EMBO J 14(23):5939-46 {{SGDpaper|S000046186}} PMID 8846786</ref><ref name='S000040393'>Niederacher D and Entian KD (1987) Isolation and characterization of the regulatory HEX2 gene necessary for glucose repression in yeast. Mol Gen Genet 206(3):505-9
+'''Description of YDR028C:''' Regulatory subunit of type 1 protein phosphatase Glc7p, involved in negative regulation of glucose-repressible genes<ref name='S000055740'>Frederick DL and Tatchell K (1996) The REG2 gene of Saccharomyces cerevisiae encodes a type 1 protein phosphatase-binding protein that functions with Reg1p and the Snf1 protein kinase to regulate growth. Mol Cell Biol 16(6):2922-31 {{SGDpaper|S000055740}} PMID 8649403</ref><ref name='S000040393'>Niederacher D and Entian KD (1987) Isolation and characterization of the regulatory HEX2 gene necessary for glucose repression in yeast. Mol Gen Genet 206(3):505-9 {{SGDpaper|S000040393}} PMID 3035346</ref><ref name='S000046186'>Tu J and Carlson M (1995) REG1 binds to protein phosphatase type 1 and regulates glucose repression in Saccharomyces cerevisiae. EMBO J 14(23):5939-46
-  {{SGDpaper|S000040393}} PMID 3035346</ref>
+  {{SGDpaper|S000046186}} PMID 8846786</ref>
 <br>
 <br>
 <br>
 <br>
+<br>
+</protect>
+__TOC__
+==Community Commentary==
+{{CommentaryHelp}}
 === Alleles, Strains, and Phenotypes ===
 [[Category:Topic:Alleles, Strains, and Phenotypes]]
@@ Line 149: / Line 155: @@
 Deletion of SNF1 suppresses the hyperinvasive phenotype of reg1. <ref name='S000070028'>Kuchin S, et al. (2002) Snf1 protein kinase and the repressors Nrg1 and Nrg2 regulate FLO11, haploid invasive growth, and diploid pseudohyphal differentiation. Mol Cell Biol 22(12):3994-4000 {{SGDpaper|S000070028}} PMID 12024013</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref>
-{{ShortCenteredHR}}
-'''Strain Background''': Sigma1278b (Sigma2000 series)<br>
-'''Genotype''': MCY4618<br>
-'''Together with''': SIP1, GAL83, SIP2, MUC1<br>
-'''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]], FLO11/MUC1 promoter substituted with S.p.Adh+ promoter [[Category:Phenotype:FLO11/MUC1 promoter substituted with S.p.Adh+ promoter]]
-Deletion of REG1 in cells where FLO11/MUC1 expression is clamped (by substitution of the FLO11 promoter with the S.pombe Adh+promoter) causes an increase in invasion. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref>
-{{ShortCenteredHR}}
-__TOC__
-==Community Commentary==
-{{CommentaryHelp}}
-=== Alleles, Strains, and Phenotypes ===
-[[Category:Topic:Alleles, Strains, and Phenotypes]]
-==== Complete Deletion ====
-[[Category:Topic:Alleles, Strains, and Phenotypes:Complete Deletion]]
-'''Allele''': reg1::URA3<br>
-'''Strain Background''': Sigma1278b (Sigma2000 series)<br>
-'''Genotype''': MCY4569<br>
-'''Together with''': SIP1, GAL83, SIP2, MUC1<br>
-'''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]]
-reg1 mutants are consitutively filamentous (filamentous even in the presence of glucose, unlike wild-type, which filaments on media lacking glucose). <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref>
-{{ShortCenteredHR}}
-'''Allele''': reg1::URA3<br>
-'''Strain Background''': Sigma1278b (Sigma2000 series)<br>
-'''Genotype''': MCY4569<br>
-'''Together with''': SIP1, GAL83, SIP2, MUC1<br>
-'''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]]
-reg1 mutants display a constitutive invasive phenotype (they invade better than wild-type on medium containing high glucose (2%), but about the same as wild-type in limiting glucose (0.1%)). <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref>
-{{ShortCenteredHR}}
-'''Allele''': reg1::URA3<br>
-'''Strain Background''': Sigma1278b (Sigma2000 series)<br>
-'''Genotype''': MCY4569<br>
-'''Together with''': SIP1, GAL83, SIP2, MUC1<br>
-'''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]]
-reg1 mutants are consitutively filamentous (filamentous even in the presence of glucose, unlike wild-type, which filaments on media lacking glucose). <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref>
-{{ShortCenteredHR}}
-'''Allele''': reg1::URA3<br>
-'''Strain Background''': Sigma1278b (Sigma2000 series)<br>
-'''Genotype''': MCY4569<br>
-'''Together with''': SIP1, GAL83, SIP2, MUC1<br>
-'''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]]
-reg1 mutants display a constitutive invasive phenotype (they invade better than wild-type on medium containing high glucose (2%), but about the same as wild-type in limiting glucose (0.1%)). <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref>
-{{ShortCenteredHR}}
-'''Allele''': reg1::URA3<br>
-'''Strain Background''': Sigma1278b (Sigma2000 series)<br>
-'''Genotype''': MCY4462<br>
-'''Together with''': SNF1<br>
-'''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]]
-reg1 mutants invade better than wild-type. <ref name='S000070028'>Kuchin S, et al. (2002) Snf1 protein kinase and the repressors Nrg1 and Nrg2 regulate FLO11, haploid invasive growth, and diploid pseudohyphal differentiation. Mol Cell Biol 22(12):3994-4000 {{SGDpaper|S000070028}} PMID 12024013</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref>
-{{ShortCenteredHR}}
-==== Multiple Knockout Strains ====
-[[Category:Topic:Alleles, Strains, and Phenotypes:Multiple Knockout Strains]]
-'''Strain Background''': Sigma1278b (Sigma2000 series)<br>
-'''Genotype''': MCY4469<br>
-'''Together with''': SIP1, GAL83, SIP2, MUC1<br>
-'''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]]
-Deletion of FLO11/MUC1 suppresses reg1's constitutive invasion phenotype, but not its constitutive filamentous phenotype. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref>
-{{ShortCenteredHR}}
-'''Strain Background''': Sigma1278b (Sigma2000 series)<br>
-'''Genotype''': MCY4571<br>
-'''Together with''': SIP1, GAL83, SIP2, MUC1<br>
-'''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]]
-Deletion of GAL83 suppresses reg1's constitutive adherance to plastic (adherance in high glucose (2%)). <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref>
-{{ShortCenteredHR}}
-'''Strain Background''': Sigma1278b (Sigma 2000 series)<br>
-'''Genotype''': MCY4633<br>
-'''Together with''': SIP1, GAL83, SIP2, MUC1<br>
-'''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]]
-Deletion of both SIP2 and GAL83 in a reg1 mutant suppresses its constitutive filamentous phenotype. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref>
-{{ShortCenteredHR}}
-'''Strain Background''': Sigma1278b (Sigma2000 series)<br>
-'''Genotype''': MCY4571<br>
-'''Together with''': SIP1, GAL83, SIP2, MUC1<br>
-'''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]]
-Deletion of GAL83 suppresses reg1's constitutive adherance to plastic (adherance in high glucose (2%)). <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref>
-{{ShortCenteredHR}}
-'''Strain Background''': Sigma1278b (Sigma2000 series)<br>
-'''Genotype''': MCY4469<br>
-'''Together with''': SIP1, GAL83, SIP2, MUC1<br>
-'''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]]
-Deletion of FLO11/MUC1 suppresses reg1's constitutive invasion phenotype, but not its constitutive filamentous phenotype. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref>
-{{ShortCenteredHR}}
-'''Strain Background''': Sigma1278b (Sigma 2000 series)<br>
-'''Genotype''': MCY4633<br>
-'''Together with''': SIP1, GAL83, SIP2, MUC1<br>
-'''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]]
-Deletion of both SIP2 and GAL83 in a reg1 mutant suppresses its constitutive filamentous phenotype. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref>
 {{ShortCenteredHR}}
@@ Line 283: / Line 167: @@
 {{ShortCenteredHR}}
-'''Strain Background''': Sigma1278b<br>
-'''Genotype''': MCY4461<br>
-'''Together with''': SNF1<br>
-'''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]]
-Deletion of SNF1 suppresses the hyperinvasive phenotype of reg1. <ref name='S000070028'>Kuchin S, et al. (2002) Snf1 protein kinase and the repressors Nrg1 and Nrg2 regulate FLO11, haploid invasive growth, and diploid pseudohyphal differentiation. Mol Cell Biol 22(12):3994-4000 {{SGDpaper|S000070028}} PMID 12024013</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref>
-{{ShortCenteredHR}}
+<!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation -->
+<!--
+Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
+<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
+J Biol Chem 278(5):3265-74</ref>
+-->
-'''Strain Background''': Sigma1278b (Sigma2000 series)<br>
-'''Genotype''': MCY4618<br>
-'''Together with''': SIP1, GAL83, SIP2, MUC1<br>
-'''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]], FLO11/MUC1 promoter substituted with S.p.Adh+ promoter [[Category:Phenotype:FLO11/MUC1 promoter substituted with S.p.Adh+ promoter]]
-Deletion of REG1 in cells where FLO11/MUC1 expression is clamped (by substitution of the FLO11 promoter with the S.pombe Adh+promoter) causes an increase in invasion. <ref name='S000072732'>Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 {{SGDpaper|S000072732}} PMID 12556493</ref> <ref name = 'CAset6176-2003-03-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=6176 Valmik K. Vyas] on 2003-03-27</ref>
-{{ShortCenteredHR}}
+<protect>
 ==References==
 <!-- REFERENCES ARE AUTOMATICALLY GENERATED.  PLEASE DON'T EDIT THIS SECTION-->
 {{RefHelp}}
+</protect>

Difference between revisions of "YDR028C"

Latest revision as of 07:45, 23 January 2012

Contents

Community Commentary

Alleles, Strains, and Phenotypes

Complete Deletion

Multiple Knockout Strains

References

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