YDL142C

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Systematic name YDL142C
Gene name CRD1
Aliases CLS1
Feature type ORF, Verified
Coordinates Chr IV:202571..201720


Description of YDL142C: Cardiolipin synthase; produces cardiolipin, which is an important constituent of mitochondrial membranes; required for normal mitochondrial membrane potential and function[1][2][3][4]




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References

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  1. Zhang M, et al. (2003) Cardiolipin is not required to maintain mitochondrial DNA stability or cell viability for Saccharomyces cerevisiae grown at elevated temperatures. J Biol Chem 278(37):35204-10 SGD PMID 12840009
  2. Jiang F, et al. (1999) Cardiolipin synthase expression is essential for growth at elevated temperature and is regulated by factors affecting mitochondrial development. Mol Microbiol 31(1):373-9 SGD PMID 9987137
  3. Jiang F, et al. (2000) Absence of cardiolipin in the crd1 null mutant results in decreased mitochondrial membrane potential and reduced mitochondrial function. J Biol Chem 275(29):22387-94 SGD PMID 10777514
  4. Chang SC, et al. (1998) Isolation and characterization of the gene (CLS1) encoding cardiolipin synthase in Saccharomyces cerevisiae. J Biol Chem 273(24):14933-41 SGD PMID 9614098

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