YDL042C

From SGD-Wiki
Revision as of 14:05, 4 September 2012 by SGDwikiBot (talk | contribs) (Automated import of articles)
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search

Share your knowledge...Edit this entry! <protect>

Systematic name YDL042C
Gene name SIR2
Aliases MAR1
Feature type ORF, Verified
Coordinates Chr IV:378445..376757
Primary SGDID S000002200


Description of YDL042C: Conserved NAD+ dependent histone deacetylase of the Sirtuin family; involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and the rDNA locus; negatively regulates initiation of DNA replication; functions as a regulator of autophagy like mammalian homolog SIRT1, and also of mitophagy[1][2][3][4][5]




</protect>

Community Commentary

About Community Commentary. Please share your knowledge!




<protect>

References

See Help:References on how to add references

  1. Gottlieb S and Esposito RE (1989) A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA. Cell 56(5):771-6 SGD PMID 2647300
  2. Landry J, et al. (2000) The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Proc Natl Acad Sci U S A 97(11):5807-11 SGD PMID 10811920
  3. Pappas DL Jr, et al. (2004) The NAD(+)-dependent Sir2p histone deacetylase is a negative regulator of chromosomal DNA replication. Genes Dev 18(7):769-81 SGD PMID 15082529
  4. Rine J and Herskowitz I (1987) Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae. Genetics 116(1):9-22 SGD PMID 3297920
  5. Sampaio-Marques B, et al. (2012) SNCA (alpha-synuclein)-induced toxicity in yeast cells is dependent on sirtuin 2 (Sir2)-mediated mitophagy. Autophagy 8(10) SGD PMID 22914317

See Help:Categories on how to add the wiki page for this gene to a Category </protect>