Difference between revisions of "YDL042C"
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| − | '''Description of YDL042C:''' Conserved NAD+ dependent histone deacetylase of the Sirtuin family involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and the rDNA locus; negatively regulates initiation of DNA replication<ref name='S000054554'>Gottlieb S and Esposito RE (1989) A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA. Cell 56(5):771-6 {{SGDpaper|S000054554}} PMID 2647300</ref><ref name='S000041050'>Landry J, et al. (2000) The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Proc Natl Acad Sci U S A 97(11):5807-11 {{SGDpaper|S000041050}} PMID 10811920</ref><ref name='S000076193'>Pappas DL Jr, et al. (2004) The NAD(+)-dependent Sir2p histone deacetylase is a negative regulator of chromosomal DNA replication. Genes Dev 18(7):769-81 {{SGDpaper|S000076193}} PMID 15082529</ref><ref name='S000043450'>Rine J and Herskowitz I (1987) Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae. Genetics 116(1):9-22 | + | '''Description of YDL042C:''' Conserved NAD+ dependent histone deacetylase of the Sirtuin family; involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and the rDNA locus; negatively regulates initiation of DNA replication; functions as a regulator of autophagy like mammalian homolog SIRT1, and also of mitophagy<ref name='S000054554'>Gottlieb S and Esposito RE (1989) A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA. Cell 56(5):771-6 {{SGDpaper|S000054554}} PMID 2647300</ref><ref name='S000041050'>Landry J, et al. (2000) The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Proc Natl Acad Sci U S A 97(11):5807-11 {{SGDpaper|S000041050}} PMID 10811920</ref><ref name='S000076193'>Pappas DL Jr, et al. (2004) The NAD(+)-dependent Sir2p histone deacetylase is a negative regulator of chromosomal DNA replication. Genes Dev 18(7):769-81 {{SGDpaper|S000076193}} PMID 15082529</ref><ref name='S000043450'>Rine J and Herskowitz I (1987) Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae. Genetics 116(1):9-22 {{SGDpaper|S000043450}} PMID 3297920</ref><ref name='S000150576'>Sampaio-Marques B, et al. (2012) SNCA (alpha-synuclein)-induced toxicity in yeast cells is dependent on sirtuin 2 (Sir2)-mediated mitophagy. Autophagy 8(10) |
| − | {{SGDpaper| | + | {{SGDpaper|S000150576}} PMID 22914317</ref> |
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Latest revision as of 14:05, 4 September 2012
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| Systematic name | YDL042C |
| Gene name | SIR2 |
| Aliases | MAR1 |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:378445..376757 |
| Primary SGDID | S000002200 |
Description of YDL042C: Conserved NAD+ dependent histone deacetylase of the Sirtuin family; involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and the rDNA locus; negatively regulates initiation of DNA replication; functions as a regulator of autophagy like mammalian homolog SIRT1, and also of mitophagy[1][2][3][4][5]
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References
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- ↑ Gottlieb S and Esposito RE (1989) A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA. Cell 56(5):771-6 SGD PMID 2647300
- ↑ Landry J, et al. (2000) The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Proc Natl Acad Sci U S A 97(11):5807-11 SGD PMID 10811920
- ↑ Pappas DL Jr, et al. (2004) The NAD(+)-dependent Sir2p histone deacetylase is a negative regulator of chromosomal DNA replication. Genes Dev 18(7):769-81 SGD PMID 15082529
- ↑ Rine J and Herskowitz I (1987) Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae. Genetics 116(1):9-22 SGD PMID 3297920
- ↑ Sampaio-Marques B, et al. (2012) SNCA (alpha-synuclein)-induced toxicity in yeast cells is dependent on sirtuin 2 (Sir2)-mediated mitophagy. Autophagy 8(10) SGD PMID 22914317
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