Difference between revisions of "YDL020C"

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'''Description of YDL020C:''' Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses<ref name='S000069483'>Owsianik G, et al. (2002) Control of 26S proteasome expression by transcription factors regulating multidrug resistance in Saccharomyces cerevisiae. Mol Microbiol 43(5):1295-308 {{SGDpaper|S000069483}} PMID 11918814</ref><ref name='S000061866'>Mannhaupt G, et al. (1999) Rpn4p acts as a transcription factor by binding to PACE, a nonamer box found upstream of 26S proteasomal and other genes in yeast. FEBS Lett 450(1-2):27-34 {{SGDpaper|S000061866}} PMID 10350051</ref><ref name='S000059915'>Xie Y and Varshavsky A (2001) RPN4 is a ligand, substrate, and transcriptional regulator of the 26S proteasome: a negative feedback circuit. Proc Natl Acad Sci U S A 98(6):3056-61 {{SGDpaper|S000059915}} PMID 11248031</ref><ref name='S000049671'>Ng DT, et al. (2000) The unfolded protein response regulates multiple aspects of secretory and membrane protein biogenesis and endoplasmic reticulum quality control. J Cell Biol 150(1):77-88
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'''Description of YDL020C:''' Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses<ref name='S000049671'>Ng DT, et al. (2000) The unfolded protein response regulates multiple aspects of secretory and membrane protein biogenesis and endoplasmic reticulum quality control. J Cell Biol 150(1):77-88 {{SGDpaper|S000049671}} PMID 10893258</ref><ref name='S000059915'>Xie Y and Varshavsky A (2001) RPN4 is a ligand, substrate, and transcriptional regulator of the 26S proteasome: a negative feedback circuit. Proc Natl Acad Sci U S A 98(6):3056-61 {{SGDpaper|S000059915}} PMID 11248031</ref><ref name='S000061866'>Mannhaupt G, et al. (1999) Rpn4p acts as a transcription factor by binding to PACE, a nonamer box found upstream of 26S proteasomal and other genes in yeast. FEBS Lett 450(1-2):27-34 {{SGDpaper|S000061866}} PMID 10350051</ref><ref name='S000069483'>Owsianik G, et al. (2002) Control of 26S proteasome expression by transcription factors regulating multidrug resistance in Saccharomyces cerevisiae. Mol Microbiol 43(5):1295-308
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  {{SGDpaper|S000069483}} PMID 11918814</ref>
 
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Revision as of 14:05, 31 March 2009

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Systematic name YDL020C
Gene name RPN4
Aliases SON1, UFD5
Feature type ORF, Verified
Coordinates Chr IV:416706..415111
Primary SGDID S000002178


Description of YDL020C: Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses[1][2][3][4]




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References

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  1. Ng DT, et al. (2000) The unfolded protein response regulates multiple aspects of secretory and membrane protein biogenesis and endoplasmic reticulum quality control. J Cell Biol 150(1):77-88 SGD PMID 10893258
  2. Xie Y and Varshavsky A (2001) RPN4 is a ligand, substrate, and transcriptional regulator of the 26S proteasome: a negative feedback circuit. Proc Natl Acad Sci U S A 98(6):3056-61 SGD PMID 11248031
  3. Mannhaupt G, et al. (1999) Rpn4p acts as a transcription factor by binding to PACE, a nonamer box found upstream of 26S proteasomal and other genes in yeast. FEBS Lett 450(1-2):27-34 SGD PMID 10350051
  4. Owsianik G, et al. (2002) Control of 26S proteasome expression by transcription factors regulating multidrug resistance in Saccharomyces cerevisiae. Mol Microbiol 43(5):1295-308 SGD PMID 11918814

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