Difference between revisions of "YDL013W"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002171 YDL013W]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002171 YDL013W]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''HEX3 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''SLX5 ''
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases'''          ||''SLX5''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases'''          ||''HEX3, ULS2''
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type'''          || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type'''          || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr IV:429064..430923
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|nowrap| Chr IV:429067..430926
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000002171
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000002171
 
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'''Description of YDL013W:''' Protein containing a RING finger domain that interacts with Slx8p; mutant phenotypes and genetic interactions suggest a role in sumoylation and in genome stability<ref name='S000113976'>Wang Z, et al. (2006) Genetic Analysis Connects SLX5 and SLX8 to the SUMO Pathway in Saccharomyces cerevisiae. Genetics 172(3):1499-509 {{SGDpaper|S000113976}} PMID 16387868</ref><ref name='S000059086'>Mullen JR, et al. (2001) Requirement for three novel protein complexes in the absence of the Sgs1 DNA helicase in Saccharomyces cerevisiae. Genetics 157(1):103-18
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'''Description of YDL013W:''' Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex, stimulated by SUMO-modified substrates; contains a RING domain and two SIMs (SUMO-interacting motifs); forms SUMO-dependent nuclear foci, including DNA repair centers<ref name='S000129620'>Cook CE, et al. (2009) The SUMO-targeted ubiquitin ligase subunit Slx5 resides in nuclear foci and at sites of DNA breaks. Cell Cycle 8(7):1080-9 {{SGDpaper|S000129620}} PMID 19270524</ref><ref name='S000124762'>Ii T, et al. (2007) The yeast Slx5-Slx8 DNA integrity complex displays ubiquitin ligase activity. Cell Cycle 6(22):2800-9 {{SGDpaper|S000124762}} PMID 18032921</ref><ref name='S000059086'>Mullen JR, et al. (2001) Requirement for three novel protein complexes in the absence of the Sgs1 DNA helicase in Saccharomyces cerevisiae. Genetics 157(1):103-18 {{SGDpaper|S000059086}} PMID 11139495</ref><ref name='S000113976'>Wang Z, et al. (2006) Genetic Analysis Connects SLX5 and SLX8 to the SUMO Pathway in Saccharomyces cerevisiae. Genetics 172(3):1499-509 {{SGDpaper|S000113976}} PMID 16387868</ref><ref name='S000124057'>Xie Y, et al. (2007) The Yeast Hex3{middle dot}Slx8 Heterodimer Is a Ubiquitin Ligase Stimulated by Substrate Sumoylation. J Biol Chem 282(47):34176-84
  {{SGDpaper|S000059086}} PMID 11139495</ref>
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  {{SGDpaper|S000124057}} PMID 17848550</ref>
 
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Latest revision as of 07:45, 23 January 2012

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Systematic name YDL013W
Gene name SLX5
Aliases HEX3, ULS2
Feature type ORF, Verified
Coordinates Chr IV:429067..430926
Primary SGDID S000002171


Description of YDL013W: Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex, stimulated by SUMO-modified substrates; contains a RING domain and two SIMs (SUMO-interacting motifs); forms SUMO-dependent nuclear foci, including DNA repair centers[1][2][3][4][5]




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References

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  1. Cook CE, et al. (2009) The SUMO-targeted ubiquitin ligase subunit Slx5 resides in nuclear foci and at sites of DNA breaks. Cell Cycle 8(7):1080-9 SGD PMID 19270524
  2. Ii T, et al. (2007) The yeast Slx5-Slx8 DNA integrity complex displays ubiquitin ligase activity. Cell Cycle 6(22):2800-9 SGD PMID 18032921
  3. Mullen JR, et al. (2001) Requirement for three novel protein complexes in the absence of the Sgs1 DNA helicase in Saccharomyces cerevisiae. Genetics 157(1):103-18 SGD PMID 11139495
  4. Wang Z, et al. (2006) Genetic Analysis Connects SLX5 and SLX8 to the SUMO Pathway in Saccharomyces cerevisiae. Genetics 172(3):1499-509 SGD PMID 16387868
  5. Xie Y, et al. (2007) The Yeast Hex3{middle dot}Slx8 Heterodimer Is a Ubiquitin Ligase Stimulated by Substrate Sumoylation. J Biol Chem 282(47):34176-84 SGD PMID 17848550

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