Difference between revisions of "YCR079W"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''PTC6 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''PTC6 ''
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases'''          ||''AUP1''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases'''          ||''AUP1, PPP2''
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type'''          || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type'''          || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
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'''Description of YCR079W:''' Phosphoprotein phosphatase type 2C similar to mammalian PP1Ks; involved in mitophagy; localized to mitochondrial inner membrane space; null mutant is sensitive to rapamycin<ref name='S000120041'>Tal R, et al. (2007) Aup1p, a yeast mitochondrial protein phosphatase homolog, is required for efficient stationary phase mitophagy and cell survival. J Biol Chem 282(8):5617-24 {{SGDpaper|S000120041}} PMID 17166847</ref><ref name='S000118976'>Ruan H, et al. (2007) The YCR079w gene confers a rapamycin-resistant function and encodes the sixth type 2C protein phosphatase in Saccharomyces cerevisiae. FEMS Yeast Res 7(2):209-15 {{SGDpaper|S000118976}} PMID 17002782</ref><ref name='S000063829'>Tomaska L (2000) Mitochondrial protein phosphorylation: lessons from yeasts. Gene 255(1):59-64 {{SGDpaper|S000063829}} PMID 10974565</ref><ref name='S000042149'>Sakumoto N, et al. (1999) A series of protein phosphatase gene disruptants in Saccharomyces cerevisiae. Yeast 15(15):1669-79
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'''Description of YCR079W:''' Mitochondrial type 2C protein phosphatase involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc5p<ref name='S000125220'>Gey U, et al. (2008) Yeast pyruvate dehydrogenase complex is regulated by a concerted activity of two kinases and two phosphatases. J Biol Chem  {{SGDpaper|S000125220}} PMID 18180296</ref><ref name='S000120041'>Tal R, et al. (2007) Aup1p, a yeast mitochondrial protein phosphatase homolog, is required for efficient stationary phase mitophagy and cell survival. J Biol Chem 282(8):5617-24 {{SGDpaper|S000120041}} PMID 17166847</ref><ref name='S000118976'>Ruan H, et al. (2007) The YCR079w gene confers a rapamycin-resistant function and encodes the sixth type 2C protein phosphatase in Saccharomyces cerevisiae. FEMS Yeast Res 7(2):209-15 {{SGDpaper|S000118976}} PMID 17002782</ref><ref name='S000063829'>Tomaska L (2000) Mitochondrial protein phosphorylation: lessons from yeasts. Gene 255(1):59-64 {{SGDpaper|S000063829}} PMID 10974565</ref><ref name='S000042149'>Sakumoto N, et al. (1999) A series of protein phosphatase gene disruptants in Saccharomyces cerevisiae. Yeast 15(15):1669-79
 
  {{SGDpaper|S000042149}} PMID 10572263</ref>
 
  {{SGDpaper|S000042149}} PMID 10572263</ref>
 
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Revision as of 14:05, 21 March 2008

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Systematic name YCR079W
Gene name PTC6
Aliases AUP1, PPP2
Feature type ORF, Verified
Coordinates Chr III:252842..254170
Primary SGDID S000002133


Description of YCR079W: Mitochondrial type 2C protein phosphatase involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc5p[1][2][3][4][5]




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References

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  1. Gey U, et al. (2008) Yeast pyruvate dehydrogenase complex is regulated by a concerted activity of two kinases and two phosphatases. J Biol Chem SGD PMID 18180296
  2. Tal R, et al. (2007) Aup1p, a yeast mitochondrial protein phosphatase homolog, is required for efficient stationary phase mitophagy and cell survival. J Biol Chem 282(8):5617-24 SGD PMID 17166847
  3. Ruan H, et al. (2007) The YCR079w gene confers a rapamycin-resistant function and encodes the sixth type 2C protein phosphatase in Saccharomyces cerevisiae. FEMS Yeast Res 7(2):209-15 SGD PMID 17002782
  4. Tomaska L (2000) Mitochondrial protein phosphorylation: lessons from yeasts. Gene 255(1):59-64 SGD PMID 10974565
  5. Sakumoto N, et al. (1999) A series of protein phosphatase gene disruptants in Saccharomyces cerevisiae. Yeast 15(15):1669-79 SGD PMID 10572263

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