Difference between revisions of "YCL063W"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YCL063W YCL063W]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000568 YCL063W]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''VAC17 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''VAC17 ''
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|nowrap| Chr III:17290..18561
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000000568
 
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'''Description of {{PAGENAME}}:''' Protein involved in vacuole inheritance; acts as a vacuole-specific receptor for myosin Myo2p<ref name='S000072781'>Ishikawa K, et al. (2003) Identification of an organelle-specific myosin V receptor. J Cell Biol 160(6):887-97 {{SGDpaper|S000072781}} PMID 12642614</ref><ref name='S000072665'>Tang F, et al. (2003) Regulated degradation of a class V myosin receptor directs movement of the yeast vacuole. Nature 422(6927):87-92
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'''Description of YCL063W:''' Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p<ref name='S000129348'>Bartholomew CR and Hardy CF (2009) p21-activated kinases Cla4 and Ste20 regulate vacuole inheritance in Saccharomyces cerevisiae. Eukaryot Cell 8(4):560-72 {{SGDpaper|S000129348}} PMID 19218422</ref><ref name='S000072781'>Ishikawa K, et al. (2003) Identification of an organelle-specific myosin V receptor. J Cell Biol 160(6):887-97 {{SGDpaper|S000072781}} PMID 12642614</ref><ref name='S000072665'>Tang F, et al. (2003) Regulated degradation of a class V myosin receptor directs movement of the yeast vacuole. Nature 422(6927):87-92
 
  {{SGDpaper|S000072665}} PMID 12594460</ref>
 
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==Community Commentary==
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=== Alleles, Strains, and Phenotypes ===
 
=== Alleles, Strains, and Phenotypes ===
 
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==Community Commentary==
 
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=== Alleles, Strains, and Phenotypes ===
 
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[[Category:Topic:Alleles, Strains, and Phenotypes]]
 
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==== Partial Deletion ====
 
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[[Category:Topic:Alleles, Strains, and Phenotypes:Partial Deletion]]
 
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'''Strain Background''': LWY 7235<br>
 
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'''Genotype''': LWY 5798 (vac17::TRP1)<br>
 
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'''Phenotype(s)''': Loss of function (Null) [[Category:Phenotype:Loss of function (Null)]], Recessive [[Category:Phenotype:Recessive]], Viable [[Category:Phenotype:Viable]]
 
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'''Mutation type(s)''': Partial deletion from 17364 to partialDelTo
 
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In LWY5798, residues 26-357 of Vac17p was substituted with the TRP1 gene. <ref name='S000072665'>Tang F, et al. (2003) Regulated degradation of a class V myosin receptor directs movement of the yeast vacuole. Nature 422(6927):87-92 {{SGDpaper|S000072665}} PMID 12594460</ref> <ref name = 'CAset5804-2003-03-17'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=5804 Fusheng Tang] on 2003-03-17</ref>
 
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=== Interactions ===
 
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[[Category:Topic:Interactions]]
 
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==== Physical ====
 
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[[Category:Topic:Interactions:Physical]]
 
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Physical interaction with VAC8 [[Category:Physical Interactions with VAC8]]<br>
 
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Immunoprecipitating Vac17p with sheep anti-Vac17p antibody coprecipitates Vac8p. <ref name='S000072665'>Tang F, et al. (2003) Regulated degradation of a class V myosin receptor directs movement of the yeast vacuole. Nature 422(6927):87-92 {{SGDpaper|S000072665}} PMID 12594460</ref> <ref name = 'CAset5804-2003-03-17'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=5804 Fusheng Tang] on 2003-03-17</ref>
 
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Physical interaction with MYO2 [[Category:Physical Interactions with MYO2]]<br>
 
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Immunoprecipitating Vac17p with sheep anti-Vac17p antibody coprecipitates Myo2p. <ref name='S000072665'>Tang F, et al. (2003) Regulated degradation of a class V myosin receptor directs movement of the yeast vacuole. Nature 422(6927):87-92 {{SGDpaper|S000072665}} PMID 12594460</ref> <ref name = 'CAset5804-2003-03-17'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=5804 Fusheng Tang] on 2003-03-17</ref>
 
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==== Two Hybrid ====
 
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[[Category:Topic:Interactions:Two Hybrid]]
 
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Two Hybrid interaction with VAC8 [[Category:Two Hybrid Interactions with VAC8]]<br>
 
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Residues 290-380 of Vac17p interact with Vac8p in a yeast two-hybrid analysis. <ref name='S000072665'>Tang F, et al. (2003) Regulated degradation of a class V myosin receptor directs movement of the yeast vacuole. Nature 422(6927):87-92 {{SGDpaper|S000072665}} PMID 12594460</ref> <ref name = 'CAset5804-2003-03-17'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=5804 Fusheng Tang] on 2003-03-17</ref>
 
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=== Protein Details ===
 
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[[Category:Topic:Protein Details]]
 
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==== Protein Degradation ====
 
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[[Category:Topic:Protein Details:Protein Degradation]]
 
  
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Vac17p contains a PEST sequence, a rapid degradation signal. The PEST-dependent degradation appears to occur in the bud after vacuoles arrive in the bud. <ref name='S000072665'>Tang F, et al. (2003) Regulated degradation of a class V myosin receptor directs movement of the yeast vacuole. Nature 422(6927):87-92 {{SGDpaper|S000072665}} PMID 12594460</ref> <ref name = 'CAset5804-2003-03-17'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=5804 Fusheng Tang] on 2003-03-17</ref>
 
  
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==== Protein Function/Process ====
 
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Vac17p is involved in vacuole inheritance. Deletion of VAC17 gene blocks vacuole inheritance. Vac17p functions as the vacuole-specific Myp2p receptor. It forms a complex with Myo2p and Vac8p, a vacuolar membrane protein. Vac17p connects Myo2p to Vac8p and thus the vacuole membrane. <ref name='S000072665'>Tang F, et al. (2003) Regulated degradation of a class V myosin receptor directs movement of the yeast vacuole. Nature 422(6927):87-92 {{SGDpaper|S000072665}} PMID 12594460</ref> <ref name = 'CAset5804-2003-03-17'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=5804 Fusheng Tang] on 2003-03-17</ref>
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.  
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J Biol Chem 278(5):3265-74</ref>
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==== Protein Localization ====
 
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[[Category:Topic:Protein Details:Protein Localization]]
 
  
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Vac17p is localized on the vacuole membrane in a Vac8p-dependent manner. <ref name='S000072665'>Tang F, et al. (2003) Regulated degradation of a class V myosin receptor directs movement of the yeast vacuole. Nature 422(6927):87-92 {{SGDpaper|S000072665}} PMID 12594460</ref> <ref name = 'CAset5804-2003-03-17'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=5804 Fusheng Tang] on 2003-03-17</ref>
 
  
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==References==
 
==References==
 
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Latest revision as of 07:45, 23 January 2012

Share your knowledge...Edit this entry! <protect>

Systematic name YCL063W
Gene name VAC17
Aliases YCL062W
Feature type ORF, Verified
Coordinates Chr III:17290..18561
Primary SGDID S000000568


Description of YCL063W: Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p[1][2][3]




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Community Commentary

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Alleles, Strains, and Phenotypes

Partial Deletion

Strain Background: LWY 7235
Genotype: LWY 5798 (vac17::TRP1)
Phenotype(s): Loss of function (Null), Recessive, Viable Mutation type(s): Partial deletion from 17364 to partialDelTo

In LWY5798, residues 26-357 of Vac17p was substituted with the TRP1 gene. [3] [4]

Interactions

Physical

Physical interaction with VAC8
Immunoprecipitating Vac17p with sheep anti-Vac17p antibody coprecipitates Vac8p. [3] [4]

Physical interaction with MYO2
Immunoprecipitating Vac17p with sheep anti-Vac17p antibody coprecipitates Myo2p. [3] [4]

Two Hybrid

Two Hybrid interaction with VAC8
Residues 290-380 of Vac17p interact with Vac8p in a yeast two-hybrid analysis. [3] [4]

Protein Details

Protein Degradation

Vac17p contains a PEST sequence, a rapid degradation signal. The PEST-dependent degradation appears to occur in the bud after vacuoles arrive in the bud. [3] [4]

Protein Function/Process

Vac17p is involved in vacuole inheritance. Deletion of VAC17 gene blocks vacuole inheritance. Vac17p functions as the vacuole-specific Myp2p receptor. It forms a complex with Myo2p and Vac8p, a vacuolar membrane protein. Vac17p connects Myo2p to Vac8p and thus the vacuole membrane. [3] [4]

Protein Localization

Vac17p is localized on the vacuole membrane in a Vac8p-dependent manner. [3] [4]




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References

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  1. ↑ Bartholomew CR and Hardy CF (2009) p21-activated kinases Cla4 and Ste20 regulate vacuole inheritance in Saccharomyces cerevisiae. Eukaryot Cell 8(4):560-72 SGD PMID 19218422
  2. ↑ Ishikawa K, et al. (2003) Identification of an organelle-specific myosin V receptor. J Cell Biol 160(6):887-97 SGD PMID 12642614
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Tang F, et al. (2003) Regulated degradation of a class V myosin receptor directs movement of the yeast vacuole. Nature 422(6927):87-92 SGD PMID 12594460 Cite error: Invalid <ref> tag; name "S000072665" defined multiple times with different content Cite error: Invalid <ref> tag; name "S000072665" defined multiple times with different content Cite error: Invalid <ref> tag; name "S000072665" defined multiple times with different content Cite error: Invalid <ref> tag; name "S000072665" defined multiple times with different content Cite error: Invalid <ref> tag; name "S000072665" defined multiple times with different content Cite error: Invalid <ref> tag; name "S000072665" defined multiple times with different content Cite error: Invalid <ref> tag; name "S000072665" defined multiple times with different content
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 submitted by Fusheng Tang on 2003-03-17

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