YCL027W

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Systematic name YCL027W
Gene name FUS1
Aliases
Feature type ORF, Verified
Coordinates Chr III:71803..73341
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Description of YCL027W: Membrane protein localized to the shmoo tip, required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate[1][2][3][4]



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DNA and RNA Details

Other DNA and RNA Details

Other Topic: expression

Specifically higher expression in nitrogen limited chemostat cultures versus nitrogen excess. [5] [6]


Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [2] [7]


References

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  1. Nelson B, et al. (2004) Fus1p interacts with components of the Hog1p mitogen-activated protein kinase and Cdc42p morphogenesis signaling pathways to control cell fusion during yeast mating. Genetics 166(1):67-77 SGD PMID 15020407
  2. 2.0 2.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
  3. Bagnat M and Simons K (2002) Cell surface polarization during yeast mating. Proc Natl Acad Sci U S A 99(22):14183-8 SGD PMID 12374868
  4. Trueheart J, et al. (1987) Two genes required for cell fusion during yeast conjugation: evidence for a pheromone-induced surface protein. Mol Cell Biol 7(7):2316-28 SGD PMID 3302672
  5. Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. J Biol Chem 278(5):3265-74 SGD PMID 12414795
  6. submitted by Viktor Boer on 2003-07-25
  7. submitted by Jeff Ubersax on 2004-01-21

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