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Systematic name YBR252W
Gene name DUT1
Feature type ORF, Verified
Coordinates Chr II:722611..723054
Primary SGDID S000000456

Description of YBR252W: deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate[1][2][3]


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  1. Gadsden MH, et al. (1993) dUTP pyrophosphatase is an essential enzyme in Saccharomyces cerevisiae. EMBO J 12(11):4425-31 SGD PMID 8223452
  2. Guillet M, et al. (2006) dUTPase activity is critical to maintain genetic stability in Saccharomyces cerevisiae. Nucleic Acids Res 34(7):2056-66 SGD PMID 16617146
  3. Tchigvintsev A, et al. (2011) Structure and activity of the Saccharomyces cerevisiae deoxyuridine triphosphate pyrophosphatase DUT1, an essential housekeeping enzyme. Biochem J () SGD PMID 21548881

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