Difference between revisions of "YBR252W"

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'''Description of YBR252W:''' dUTPase, catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability<ref name='S000051873'>Gadsden MH, et al. (1993) dUTP pyrophosphatase is an essential enzyme in Saccharomyces cerevisiae. EMBO J 12(11):4425-31 {{SGDpaper|S000051873}} PMID 8223452</ref><ref name='S000115090'>Guillet M, et al. (2006) dUTPase activity is critical to maintain genetic stability in Saccharomyces cerevisiae. Nucleic Acids Res 34(7):2056-66
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'''Description of YBR252W:''' deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate<ref name='S000051873'>Gadsden MH, et al. (1993) dUTP pyrophosphatase is an essential enzyme in Saccharomyces cerevisiae. EMBO J 12(11):4425-31 {{SGDpaper|S000051873}} PMID 8223452</ref><ref name='S000115090'>Guillet M, et al. (2006) dUTPase activity is critical to maintain genetic stability in Saccharomyces cerevisiae. Nucleic Acids Res 34(7):2056-66 {{SGDpaper|S000115090}} PMID 16617146</ref><ref name='S000145361'>Tchigvintsev A, et al. (2011) Structure and activity of the Saccharomyces cerevisiae deoxyuridine triphosphate pyrophosphatase DUT1, an essential housekeeping enzyme. Biochem J ()
  {{SGDpaper|S000115090}} PMID 16617146</ref>
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  {{SGDpaper|S000145361}} PMID 21548881</ref>
 
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Revision as of 14:05, 23 May 2011

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Systematic name YBR252W
Gene name DUT1
Aliases
Feature type ORF, Verified
Coordinates Chr II:722611..723054
Primary SGDID S000000456


Description of YBR252W: deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate[1][2][3]




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References

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  1. Gadsden MH, et al. (1993) dUTP pyrophosphatase is an essential enzyme in Saccharomyces cerevisiae. EMBO J 12(11):4425-31 SGD PMID 8223452
  2. Guillet M, et al. (2006) dUTPase activity is critical to maintain genetic stability in Saccharomyces cerevisiae. Nucleic Acids Res 34(7):2056-66 SGD PMID 16617146
  3. Tchigvintsev A, et al. (2011) Structure and activity of the Saccharomyces cerevisiae deoxyuridine triphosphate pyrophosphatase DUT1, an essential housekeeping enzyme. Biochem J () SGD PMID 21548881

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