Difference between revisions of "YBR229C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl? | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000433 YBR229C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''ROT2 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''ROT2 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
|nowrap| Chr II:679216..676352 | |nowrap| Chr II:679216..676352 | ||
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| + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000000433 | ||
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| − | '''Description of | + | '''Description of YBR229C:''' Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations<ref name='S000064885'>Trombetta ES, et al. (1996) Endoplasmic reticulum glucosidase II is composed of a catalytic subunit, conserved from yeast to mammals, and a tightly bound noncatalytic HDEL-containing subunit. J Biol Chem 271(44):27509-16 {{SGDpaper|S000064885}} PMID 8910335</ref><ref name='S000053239'>Simons JF, et al. (1998) Cell wall 1,6-beta-glucan synthesis in Saccharomyces cerevisiae depends on ER glucosidases I and II, and the molecular chaperone BiP/Kar2p. EMBO J 17(2):396-405 {{SGDpaper|S000053239}} PMID 9430631</ref><ref name='S000050727'>Bickle M, et al. (1998) Cell wall integrity modulates RHO1 activity via the exchange factor ROM2. EMBO J 17(8):2235-45 |
{{SGDpaper|S000050727}} PMID 9545237</ref> | {{SGDpaper|S000050727}} PMID 9545237</ref> | ||
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J Biol Chem 278(5):3265-74</ref> | J Biol Chem 278(5):3265-74</ref> | ||
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Revision as of 08:45, 27 February 2007
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| Systematic name | YBR229C |
| Gene name | ROT2 |
| Aliases | GLS2 |
| Feature type | ORF, Verified |
| Coordinates | Chr II:679216..676352 |
| Primary SGDID | S000000433 |
Description of YBR229C: Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations[1][2][3]
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References
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- ↑ Trombetta ES, et al. (1996) Endoplasmic reticulum glucosidase II is composed of a catalytic subunit, conserved from yeast to mammals, and a tightly bound noncatalytic HDEL-containing subunit. J Biol Chem 271(44):27509-16 SGD PMID 8910335
- ↑ Simons JF, et al. (1998) Cell wall 1,6-beta-glucan synthesis in Saccharomyces cerevisiae depends on ER glucosidases I and II, and the molecular chaperone BiP/Kar2p. EMBO J 17(2):396-405 SGD PMID 9430631
- ↑ Bickle M, et al. (1998) Cell wall integrity modulates RHO1 activity via the exchange factor ROM2. EMBO J 17(8):2235-45 SGD PMID 9545237
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