Difference between revisions of "YBR229C"

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'''Description of YBR229C:''' Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations<ref name='S000050727'>Bickle M, et al. (1998) Cell wall integrity modulates RHO1 activity via the exchange factor ROM2. EMBO J 17(8):2235-45 {{SGDpaper|S000050727}} PMID 9545237</ref><ref name='S000053239'>Simons JF, et al. (1998) Cell wall 1,6-beta-glucan synthesis in Saccharomyces cerevisiae depends on ER glucosidases I and II, and the molecular chaperone BiP/Kar2p. EMBO J 17(2):396-405 {{SGDpaper|S000053239}} PMID 9430631</ref><ref name='S000064885'>Trombetta ES, et al. (1996) Endoplasmic reticulum glucosidase II is composed of a catalytic subunit, conserved from yeast to mammals, and a tightly bound noncatalytic HDEL-containing subunit. J Biol Chem 271(44):27509-16
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'''Description of YBR229C:''' Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations<ref name='S000064885'>Trombetta ES, et al. (1996) Endoplasmic reticulum glucosidase II is composed of a catalytic subunit, conserved from yeast to mammals, and a tightly bound noncatalytic HDEL-containing subunit. J Biol Chem 271(44):27509-16 {{SGDpaper|S000064885}} PMID 8910335</ref><ref name='S000053239'>Simons JF, et al. (1998) Cell wall 1,6-beta-glucan synthesis in Saccharomyces cerevisiae depends on ER glucosidases I and II, and the molecular chaperone BiP/Kar2p. EMBO J 17(2):396-405 {{SGDpaper|S000053239}} PMID 9430631</ref><ref name='S000050727'>Bickle M, et al. (1998) Cell wall integrity modulates RHO1 activity via the exchange factor ROM2. EMBO J 17(8):2235-45
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  {{SGDpaper|S000050727}} PMID 9545237</ref>
 
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Revision as of 14:05, 16 January 2009

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Systematic name YBR229C
Gene name ROT2
Aliases GLS2
Feature type ORF, Verified
Coordinates Chr II:679216..676352
Primary SGDID S000000433


Description of YBR229C: Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations[1][2][3]




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References

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  1. Trombetta ES, et al. (1996) Endoplasmic reticulum glucosidase II is composed of a catalytic subunit, conserved from yeast to mammals, and a tightly bound noncatalytic HDEL-containing subunit. J Biol Chem 271(44):27509-16 SGD PMID 8910335
  2. Simons JF, et al. (1998) Cell wall 1,6-beta-glucan synthesis in Saccharomyces cerevisiae depends on ER glucosidases I and II, and the molecular chaperone BiP/Kar2p. EMBO J 17(2):396-405 SGD PMID 9430631
  3. Bickle M, et al. (1998) Cell wall integrity modulates RHO1 activity via the exchange factor ROM2. EMBO J 17(8):2235-45 SGD PMID 9545237

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