Difference between revisions of "YBR223C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000427 YBR223C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''TDP1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''TDP1 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr II: | + | |nowrap| Chr II:670297..668663 |
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000000427 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000000427 | ||
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<br> | <br> | ||
| − | '''Description of YBR223C:''' Tyrosyl-DNA | + | '''Description of YBR223C:''' Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topoisomerase I and topoisomerase II; mutations in human homolog result in the neurodegenerative disease SCANI<ref name='S000123908'>He X, et al. (2007) Mutation of a Conserved Active Site Residue Converts Tyrosyl-DNA Phosphodiesterase I into a DNA Topoisomerase I-dependent Poison. J Mol Biol 372(4):1070-81 {{SGDpaper|S000123908}} PMID 17707402</ref><ref name='S000116644'>Nitiss KC, et al. (2006) Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage. Proc Natl Acad Sci U S A 103(24):8953-8 {{SGDpaper|S000116644}} PMID 16751265</ref><ref name='S000064819'>Pouliot JJ, et al. (1999) Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes. Science 286(5439):552-5 |
{{SGDpaper|S000064819}} PMID 10521354</ref> | {{SGDpaper|S000064819}} PMID 10521354</ref> | ||
<br> | <br> | ||
Latest revision as of 14:05, 5 March 2012
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| Systematic name | YBR223C |
| Gene name | TDP1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr II:670297..668663 |
| Primary SGDID | S000000427 |
Description of YBR223C: Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topoisomerase I and topoisomerase II; mutations in human homolog result in the neurodegenerative disease SCANI[1][2][3]
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References
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- ↑ He X, et al. (2007) Mutation of a Conserved Active Site Residue Converts Tyrosyl-DNA Phosphodiesterase I into a DNA Topoisomerase I-dependent Poison. J Mol Biol 372(4):1070-81 SGD PMID 17707402
- ↑ Nitiss KC, et al. (2006) Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage. Proc Natl Acad Sci U S A 103(24):8953-8 SGD PMID 16751265
- ↑ Pouliot JJ, et al. (1999) Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes. Science 286(5439):552-5 SGD PMID 10521354
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