YBR218C

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Systematic name YBR218C
Gene name PYC2
Aliases
Feature type ORF, Verified
Coordinates Chr II:662249..658707
Primary SGDID S000000422


Description of YBR218C: Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc1p but differentially regulated; mutations in the human homolog are associated with lactic acidosis[1][2][3]




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References

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  1. Brewster NK, et al. (1994) Regulation of pyruvate carboxylase isozyme (PYC1, PYC2) gene expression in Saccharomyces cerevisiae during fermentative and nonfermentative growth. Arch Biochem Biophys 311(1):62-71 SGD PMID 8185321
  2. Foury F (1997) Human genetic diseases: a cross-talk between man and yeast. Gene 195(1):1-10 SGD PMID 9300813
  3. Walker ME, et al. (1991) Yeast pyruvate carboxylase: identification of two genes encoding isoenzymes. Biochem Biophys Res Commun 176(3):1210-7 SGD PMID 2039506

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