Difference between revisions of "YBR218C"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YBR218C YBR218C]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000422 YBR218C]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''PYC2 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''PYC2 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr II:662244..658702
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|nowrap| Chr II:662249..658707
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000000422
 
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'''Description of {{PAGENAME}}:''' Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc1p but differentially regulated; mutations in the human homolog are associated with lactic acidosis<ref name='S000058196'>Foury F (1997) Human genetic diseases: a cross-talk between man and yeast. Gene 195(1):1-10 {{SGDpaper|S000058196}} PMID 9300813</ref><ref name='S000051649'>Brewster NK, et al. (1994) Regulation of pyruvate carboxylase isozyme (PYC1, PYC2) gene expression in Saccharomyces cerevisiae during fermentative and nonfermentative growth. Arch Biochem Biophys 311(1):62-71 {{SGDpaper|S000051649}} PMID 8185321</ref><ref name='S000040003'>Walker ME, et al. (1991) Yeast pyruvate carboxylase: identification of two genes encoding isoenzymes. Biochem Biophys Res Commun 176(3):1210-7
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'''Description of YBR218C:''' Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc1p but differentially regulated; mutations in the human homolog are associated with lactic acidosis<ref name='S000051649'>Brewster NK, et al. (1994) Regulation of pyruvate carboxylase isozyme (PYC1, PYC2) gene expression in Saccharomyces cerevisiae during fermentative and nonfermentative growth. Arch Biochem Biophys 311(1):62-71 {{SGDpaper|S000051649}} PMID 8185321</ref><ref name='S000058196'>Foury F (1997) Human genetic diseases: a cross-talk between man and yeast. Gene 195(1):1-10 {{SGDpaper|S000058196}} PMID 9300813</ref><ref name='S000040003'>Walker ME, et al. (1991) Yeast pyruvate carboxylase: identification of two genes encoding isoenzymes. Biochem Biophys Res Commun 176(3):1210-7
 
  {{SGDpaper|S000040003}} PMID 2039506</ref>
 
  {{SGDpaper|S000040003}} PMID 2039506</ref>
 
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==Community Commentary==
 
==Community Commentary==
 
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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==References==
 
==References==
 
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Latest revision as of 07:45, 23 January 2012

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Systematic name YBR218C
Gene name PYC2
Aliases
Feature type ORF, Verified
Coordinates Chr II:662249..658707
Primary SGDID S000000422


Description of YBR218C: Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc1p but differentially regulated; mutations in the human homolog are associated with lactic acidosis[1][2][3]




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References

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  1. Brewster NK, et al. (1994) Regulation of pyruvate carboxylase isozyme (PYC1, PYC2) gene expression in Saccharomyces cerevisiae during fermentative and nonfermentative growth. Arch Biochem Biophys 311(1):62-71 SGD PMID 8185321
  2. Foury F (1997) Human genetic diseases: a cross-talk between man and yeast. Gene 195(1):1-10 SGD PMID 9300813
  3. Walker ME, et al. (1991) Yeast pyruvate carboxylase: identification of two genes encoding isoenzymes. Biochem Biophys Res Commun 176(3):1210-7 SGD PMID 2039506

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