Difference between revisions of "YBR218C"
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| − | '''Description of YBR218C:''' Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc1p but differentially regulated; mutations in the human homolog are associated with lactic acidosis<ref name=' | + | '''Description of YBR218C:''' Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc1p but differentially regulated; mutations in the human homolog are associated with lactic acidosis<ref name='S000040003'>Walker ME, et al. (1991) Yeast pyruvate carboxylase: identification of two genes encoding isoenzymes. Biochem Biophys Res Commun 176(3):1210-7 {{SGDpaper|S000040003}} PMID 2039506</ref><ref name='S000051649'>Brewster NK, et al. (1994) Regulation of pyruvate carboxylase isozyme (PYC1, PYC2) gene expression in Saccharomyces cerevisiae during fermentative and nonfermentative growth. Arch Biochem Biophys 311(1):62-71 {{SGDpaper|S000051649}} PMID 8185321</ref><ref name='S000058196'>Foury F (1997) Human genetic diseases: a cross-talk between man and yeast. Gene 195(1):1-10 |
| − | {{SGDpaper| | + | {{SGDpaper|S000058196}} PMID 9300813</ref> |
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Revision as of 14:05, 31 March 2009
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| Systematic name | YBR218C |
| Gene name | PYC2 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr II:662244..658702 |
| Primary SGDID | S000000422 |
Description of YBR218C: Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc1p but differentially regulated; mutations in the human homolog are associated with lactic acidosis[1][2][3]
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References
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- ↑ Walker ME, et al. (1991) Yeast pyruvate carboxylase: identification of two genes encoding isoenzymes. Biochem Biophys Res Commun 176(3):1210-7 SGD PMID 2039506
- ↑ Brewster NK, et al. (1994) Regulation of pyruvate carboxylase isozyme (PYC1, PYC2) gene expression in Saccharomyces cerevisiae during fermentative and nonfermentative growth. Arch Biochem Biophys 311(1):62-71 SGD PMID 8185321
- ↑ Foury F (1997) Human genetic diseases: a cross-talk between man and yeast. Gene 195(1):1-10 SGD PMID 9300813
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