YBR215W

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Systematic name YBR215W
Gene name HPC2
Aliases
Feature type ORF, Verified
Coordinates Chr II:653351..655312
Primary SGDID S000000419


Description of YBR215W: Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes[1][2][3]




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References

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  1. Xu H, et al. (1992) Identification of a new set of cell cycle-regulatory genes that regulate S-phase transcription of histone genes in Saccharomyces cerevisiae. Mol Cell Biol 12(11):5249-59 SGD PMID 1406694
  2. Formosa T, et al. (2002) Defects in SPT16 or POB3 (yFACT) in Saccharomyces cerevisiae cause dependence on the Hir/Hpc pathway: polymerase passage may degrade chromatin structure. Genetics 162(4):1557-71 SGD PMID 12524332
  3. Prochasson P, et al. (2005) The HIR corepressor complex binds to nucleosomes generating a distinct protein/DNA complex resistant to remodeling by SWI/SNF. Genes Dev 19(21):2534-9 SGD PMID 16264190

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