Difference between revisions of "YBR195C"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000399 YBR195C]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''MSI1 ''
 
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'''Description of YBR195C:''' Subunit of chromatin assembly factor I (CAF-1), negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase; localizes to the nucleus and cytoplasm; homologous to human retinoblastoma binding proteins RbAp48 and RbAp46<ref name='S000058220'>Ach RA, et al. (1997) A conserved family of WD-40 proteins binds to the retinoblastoma protein in both plants and animals. Plant Cell 9(9):1595-606 {{SGDpaper|S000058220}} PMID 9338962</ref><ref name='S000059919'>Johnston SD, et al. (2001) CAC3(MSI1) suppression of RAS2(G19V) is independent of chromatin assembly factor I and mediated by NPR1. Mol Cell Biol 21(5):1784-94
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'''Description of YBR195C:''' Subunit of chromatin assembly factor I (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription; Msi1p localizes to both nucleus and cytoplasm and has an independent role as a negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase<ref name='S000047698'>Enomoto S and Berman J (1998) Chromatin assembly factor I contributes to the maintenance, but not the re-establishment, of silencing at the yeast silent mating loci. Genes Dev 12(2):219-32 {{SGDpaper|S000047698}} PMID 9436982</ref><ref name='S000053371'>Game JC and Kaufman PD (1999) Role of Saccharomyces cerevisiae chromatin assembly factor-I in repair of ultraviolet radiation damage in vivo. Genetics 151(2):485-97 {{SGDpaper|S000053371}} PMID 9927445</ref><ref name='S000059919'>Johnston SD, et al. (2001) CAC3(MSI1) suppression of RAS2(G19V) is independent of chromatin assembly factor I and mediated by NPR1. Mol Cell Biol 21(5):1784-94 {{SGDpaper|S000059919}} PMID 11238915</ref><ref name='S000048516'>Kaufman PD, et al. (1997) Ultraviolet radiation sensitivity and reduction of telomeric silencing in Saccharomyces cerevisiae cells lacking chromatin assembly factor-I. Genes Dev 11(3):345-57 {{SGDpaper|S000048516}} PMID 9030687</ref><ref name='S000130078'>Kim HJ, et al. (2009) Potential role of the histone chaperone, CAF-1, in transcription. BMB Rep 42(4):227-31 {{SGDpaper|S000130078}} PMID 19403047</ref><ref name='S000129017'>Kim JA and Haber JE (2009) Chromatin assembly factors Asf1 and CAF-1 have overlapping roles in deactivating the DNA damage checkpoint when DNA repair is complete. Proc Natl Acad Sci U S A 106(4):1151-6 {{SGDpaper|S000129017}} PMID 19164567</ref><ref name='S000069112'>Sharp JA, et al. (2002) Chromatin assembly factor I and Hir proteins contribute to building functional kinetochores in S. cerevisiae. Genes Dev 16(1):85-100 {{SGDpaper|S000069112}} PMID 11782447</ref><ref name='S000054483'>Smith JS, et al. (1999) A genetic screen for ribosomal DNA silencing defects identifies multiple DNA replication and chromatin-modulating factors. Mol Cell Biol 19(4):3184-97 {{SGDpaper|S000054483}} PMID 10082585</ref><ref name='S000080322'>Zabaronick SR and Tyler JK (2005) The histone chaperone anti-silencing function 1 is a global regulator of transcription independent of passage through S phase. Mol Cell Biol 25(2):652-60 {{SGDpaper|S000080322}} PMID 15632066</ref><ref name='S000114594'>Zhou H, et al. (2006) Chromatin assembly factor 1 interacts with histone H3 methylated at lysine 79 in the processes of epigenetic silencing and DNA repair. Biochemistry 45(9):2852-61
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  {{SGDpaper|S000114594}} PMID 16503640</ref>
 
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Latest revision as of 07:45, 23 January 2012

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Systematic name YBR195C
Gene name MSI1
Aliases CAC3
Feature type ORF, Verified
Coordinates Chr II:611882..610614
Primary SGDID S000000399


Description of YBR195C: Subunit of chromatin assembly factor I (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription; Msi1p localizes to both nucleus and cytoplasm and has an independent role as a negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase[1][2][3][4][5][6][7][8][9][10]




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References

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  1. ↑ Enomoto S and Berman J (1998) Chromatin assembly factor I contributes to the maintenance, but not the re-establishment, of silencing at the yeast silent mating loci. Genes Dev 12(2):219-32 SGD PMID 9436982
  2. ↑ Game JC and Kaufman PD (1999) Role of Saccharomyces cerevisiae chromatin assembly factor-I in repair of ultraviolet radiation damage in vivo. Genetics 151(2):485-97 SGD PMID 9927445
  3. ↑ Johnston SD, et al. (2001) CAC3(MSI1) suppression of RAS2(G19V) is independent of chromatin assembly factor I and mediated by NPR1. Mol Cell Biol 21(5):1784-94 SGD PMID 11238915
  4. ↑ Kaufman PD, et al. (1997) Ultraviolet radiation sensitivity and reduction of telomeric silencing in Saccharomyces cerevisiae cells lacking chromatin assembly factor-I. Genes Dev 11(3):345-57 SGD PMID 9030687
  5. ↑ Kim HJ, et al. (2009) Potential role of the histone chaperone, CAF-1, in transcription. BMB Rep 42(4):227-31 SGD PMID 19403047
  6. ↑ Kim JA and Haber JE (2009) Chromatin assembly factors Asf1 and CAF-1 have overlapping roles in deactivating the DNA damage checkpoint when DNA repair is complete. Proc Natl Acad Sci U S A 106(4):1151-6 SGD PMID 19164567
  7. ↑ Sharp JA, et al. (2002) Chromatin assembly factor I and Hir proteins contribute to building functional kinetochores in S. cerevisiae. Genes Dev 16(1):85-100 SGD PMID 11782447
  8. ↑ Smith JS, et al. (1999) A genetic screen for ribosomal DNA silencing defects identifies multiple DNA replication and chromatin-modulating factors. Mol Cell Biol 19(4):3184-97 SGD PMID 10082585
  9. ↑ Zabaronick SR and Tyler JK (2005) The histone chaperone anti-silencing function 1 is a global regulator of transcription independent of passage through S phase. Mol Cell Biol 25(2):652-60 SGD PMID 15632066
  10. ↑ Zhou H, et al. (2006) Chromatin assembly factor 1 interacts with histone H3 methylated at lysine 79 in the processes of epigenetic silencing and DNA repair. Biochemistry 45(9):2852-61 SGD PMID 16503640

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