Difference between revisions of "YBR175W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000379 YBR175W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SWD3 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SWD3 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr II: | + | |nowrap| Chr II:582408..583355 |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000000379 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000000379 | ||
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| − | '''Description of YBR175W:''' Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5<ref name=' | + | '''Description of YBR175W:''' Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5<ref name='S000076083'>Cheng H, et al. (2004) The essential WD repeat protein Swd2 has dual functions in RNA polymerase II transcription termination and lysine 4 methylation of histone H3. Mol Cell Biol 24(7):2932-43 {{SGDpaper|S000076083}} PMID 15024081</ref><ref name='S000070308'>Dover J, et al. (2002) Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6. J Biol Chem 277(32):28368-71 {{SGDpaper|S000070308}} PMID 12070136</ref><ref name='S000069538'>Krogan NJ, et al. (2002) COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. J Biol Chem 277(13):10753-5 {{SGDpaper|S000069538}} PMID 11805083</ref><ref name='S000066156'>Miller T, et al. (2001) COMPASS: a complex of proteins associated with a trithorax-related SET domain protein. Proc Natl Acad Sci U S A 98(23):12902-7 {{SGDpaper|S000066156}} PMID 11687631</ref><ref name='S000068991'>Nagy PL, et al. (2002) A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3. Proc Natl Acad Sci U S A 99(1):90-4 {{SGDpaper|S000068991}} PMID 11752412</ref><ref name='S000068755'>Roguev A, et al. (2001) The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4. EMBO J 20(24):7137-48 |
| − | {{SGDpaper| | + | {{SGDpaper|S000068755}} PMID 11742990</ref> |
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Latest revision as of 06:45, 23 January 2012
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| Systematic name | YBR175W |
| Gene name | SWD3 |
| Aliases | CPS30, SAF35 |
| Feature type | ORF, Verified |
| Coordinates | Chr II:582408..583355 |
| Primary SGDID | S000000379 |
Description of YBR175W: Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5[1][2][3][4][5][6]
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References
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- ↑ Cheng H, et al. (2004) The essential WD repeat protein Swd2 has dual functions in RNA polymerase II transcription termination and lysine 4 methylation of histone H3. Mol Cell Biol 24(7):2932-43 SGD PMID 15024081
- ↑ Dover J, et al. (2002) Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6. J Biol Chem 277(32):28368-71 SGD PMID 12070136
- ↑ Krogan NJ, et al. (2002) COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. J Biol Chem 277(13):10753-5 SGD PMID 11805083
- ↑ Miller T, et al. (2001) COMPASS: a complex of proteins associated with a trithorax-related SET domain protein. Proc Natl Acad Sci U S A 98(23):12902-7 SGD PMID 11687631
- ↑ Nagy PL, et al. (2002) A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3. Proc Natl Acad Sci U S A 99(1):90-4 SGD PMID 11752412
- ↑ Roguev A, et al. (2001) The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4. EMBO J 20(24):7137-48 SGD PMID 11742990
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