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Systematic name YBR173C
Gene name UMP1
Aliases RNS2
Feature type ORF, Verified
Coordinates Chr II:582172..581726
Primary SGDID S000000377

Description of YBR173C: Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly[1][2][3][4]


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  1. Bochtler M, et al. (1999) The proteasome. Annu Rev Biophys Biomol Struct 28:295-317 SGD PMID 10410804
  2. Li X, et al. (2007) beta-Subunit appendages promote 20S proteasome assembly by overcoming an Ump1-dependent checkpoint. EMBO J 26(9):2339-49 SGD PMID 17431397
  3. Maurizi MR (1998) Proteasome assembly: biting the hand. Curr Biol 8(13):R453-6 SGD PMID 9651672
  4. Ramos PC, et al. (1998) Ump1p is required for proper maturation of the 20S proteasome and becomes its substrate upon completion of the assembly. Cell 92(4):489-99 SGD PMID 9491890

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