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Systematic name YBR155W
Gene name CNS1
Feature type ORF, Verified
Coordinates Chr II:549765..550922
Primary SGDID S000000359

Description of YBR155W: TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion[1][2][3][4]


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YBR155W is a suppressor of CPR7

[2] [5]


Physical interaction with Hsp82
Cns1 binds both to Hsp90 and to the yeast Hsp70 protein Ssa1 with comparable affinities. This is reminiscent of Sti1, another TPR-containing co-chaperone. [4] [6]


Regulatory interaction with ssa1
Cns1 exhibits no influence on the ATPase of Hsp90. However, it activates the ATPase of Ssa1 up to 30-fold by accelerating the rate-limiting ATP hydrolysis step. This stimulating effect is mediated by the N-terminal TPR-containing part of Cns1, whereas the C-terminal part showed no effect. [4] [6]



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  1. Nathan DF, et al. (1999) Identification of SSF1, CNS1, and HCH1 as multicopy suppressors of a Saccharomyces cerevisiae Hsp90 loss-of-function mutation. Proc Natl Acad Sci U S A 96(4):1409-14 SGD PMID 9990037
  2. 2.0 2.1 Dolinski KJ, et al. (1998) CNS1 encodes an essential p60/Sti1 homolog in Saccharomyces cerevisiae that suppresses cyclophilin 40 mutations and interacts with Hsp90. Mol Cell Biol 18(12):7344-52 SGD PMID 9819421
  3. Marsh JA, et al. (1998) Cns1 is an essential protein associated with the hsp90 chaperone complex in Saccharomyces cerevisiae that can restore cyclophilin 40-dependent functions in cpr7Delta cells. Mol Cell Biol 18(12):7353-9 SGD PMID 9819422
  4. 4.0 4.1 4.2 Hainzl O, et al. (2004) Cns1 is an activator of the Ssa1 ATPase activity. J Biol Chem 279(22):23267-73 SGD PMID 15044454 Cite error: Invalid <ref> tag; name "S000076436" defined multiple times with different content Cite error: Invalid <ref> tag; name "S000076436" defined multiple times with different content
  5. submitted by Kara Dolinski on 2003-02-04
  6. 6.0 6.1 submitted by Dr. Harald Wegele on 2004-07-15

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