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Systematic name YBR140C
Gene name IRA1
Aliases GLC1, PPD1
Feature type ORF, Verified
Coordinates Chr II:526628..517350
Primary SGDID S000000344

Description of YBR140C: GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase[1][2]


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  1. Mitts MR, et al. (1991) Interactions between adenylate cyclase and the yeast GTPase-activating protein IRA1. Mol Cell Biol 11(9):4591-8 SGD PMID 1875942
  2. Tanaka K, et al. (1989) IRA1, an inhibitory regulator of the RAS-cyclic AMP pathway in Saccharomyces cerevisiae. Mol Cell Biol 9(2):757-68 SGD PMID 2540426

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