Difference between revisions of "YBR140C"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000344 YBR140C]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000344 YBR140C]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''IRA1 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''IRA1 ''

Latest revision as of 07:45, 23 January 2012

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Systematic name YBR140C
Gene name IRA1
Aliases GLC1, PPD1
Feature type ORF, Verified
Coordinates Chr II:526628..517350
Primary SGDID S000000344


Description of YBR140C: GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase[1][2]




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References

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  1. Mitts MR, et al. (1991) Interactions between adenylate cyclase and the yeast GTPase-activating protein IRA1. Mol Cell Biol 11(9):4591-8 SGD PMID 1875942
  2. Tanaka K, et al. (1989) IRA1, an inhibitory regulator of the RAS-cyclic AMP pathway in Saccharomyces cerevisiae. Mol Cell Biol 9(2):757-68 SGD PMID 2540426

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