Difference between revisions of "YBR128C"

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'''Description of YBR128C:''' Subunit of an autophagy-specific phosphatidylinositol 3-kinase complex (with Vps34p, Vps15p, and Vps30p) required for organization of a pre-autophagosomal structure; ATG14 transcription is activated by Gln3p during nitrogen starvation<ref name='S000061638'>Chan TF, et al. (2001) Regulation of APG14 expression by the GATA-type transcription factor Gln3p. J Biol Chem 276(9):6463-7 {{SGDpaper|S000061638}} PMID 11096087</ref><ref name='S000059475'>Kihara A, et al. (2001) Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J Cell Biol 152(3):519-30 {{SGDpaper|S000059475}} PMID 11157979</ref><ref name='S000050199'>Kametaka S, et al. (1998) Apg14p and Apg6/Vps30p form a protein complex essential for autophagy in the yeast, Saccharomyces cerevisiae. J Biol Chem 273(35):22284-91
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'''Description of YBR128C:''' Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I (with Vps34p, Vps15p, and Vps30p); Atg14p targets complex I to the pre-autophagosomal structure (PAS); required for localizing additional ATG proteins to the PAS<ref name='S000120821'>Suzuki K, et al. (2007) Hierarchy of Atg proteins in pre-autophagosomal structure organization. Genes Cells 12(2):209-18 {{SGDpaper|S000120821}} PMID 17295840</ref><ref name='S000059475'>Kihara A, et al. (2001) Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J Cell Biol 152(3):519-30 {{SGDpaper|S000059475}} PMID 11157979</ref><ref name='S000050199'>Kametaka S, et al. (1998) Apg14p and Apg6/Vps30p form a protein complex essential for autophagy in the yeast, Saccharomyces cerevisiae. J Biol Chem 273(35):22284-91
 
  {{SGDpaper|S000050199}} PMID 9712845</ref>
 
  {{SGDpaper|S000050199}} PMID 9712845</ref>
 
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Revision as of 14:05, 2 May 2008

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Systematic name YBR128C
Gene name ATG14
Aliases APG14, CVT12
Feature type ORF, Verified
Coordinates Chr II:494109..493075
Primary SGDID S000000332


Description of YBR128C: Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I (with Vps34p, Vps15p, and Vps30p); Atg14p targets complex I to the pre-autophagosomal structure (PAS); required for localizing additional ATG proteins to the PAS[1][2][3]




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References

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  1. Suzuki K, et al. (2007) Hierarchy of Atg proteins in pre-autophagosomal structure organization. Genes Cells 12(2):209-18 SGD PMID 17295840
  2. Kihara A, et al. (2001) Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J Cell Biol 152(3):519-30 SGD PMID 11157979
  3. Kametaka S, et al. (1998) Apg14p and Apg6/Vps30p form a protein complex essential for autophagy in the yeast, Saccharomyces cerevisiae. J Biol Chem 273(35):22284-91 SGD PMID 9712845

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