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Systematic name YBR112C
Gene name CYC8
Aliases CRT8, SSN6
Feature type ORF, Verified
Coordinates Chr II:465764..462864
Primary SGDID S000000316

Description of YBR112C: General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters[1][2]


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Other Interactions

Other Topic: functional dependence Other Interactions interaction with Nrg1
Repression by LexA-Nrg1 of a heterologous promoter containing lexA binding sites depends on Cyc8/Ssn6. [3] [4]


Physical interaction with Nrg1
Nrg1 interacts with Ssn6/Cyc8 in the two-hybrid system, and in GST pull-down experiments. [3] [4]



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  1. Proft M and Struhl K (2002) Hog1 kinase converts the Sko1-Cyc8-Tup1 repressor complex into an activator that recruits SAGA and SWI/SNF in response to osmotic stress. Mol Cell 9(6):1307-17 SGD PMID 12086627
  2. Smith RL and Johnson AD (2000) Turning genes off by Ssn6-Tup1: a conserved system of transcriptional repression in eukaryotes. Trends Biochem Sci 25(7):325-30 SGD PMID 10871883
  3. 3.0 3.1 Park SH, et al. (1999) Nrg1 is a transcriptional repressor for glucose repression of STA1 gene expression in Saccharomyces cerevisiae. Mol Cell Biol 19(3):2044-50 SGD PMID 10022891
  4. 4.0 4.1 submitted by Valmik K. Vyas on 2003-02-12

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