Difference between revisions of "YBR112C"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000316 YBR112C]  
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000316 YBR112C]  
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''CYC8 ''
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''CYC8 ''

Latest revision as of 07:45, 23 January 2012

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Systematic name YBR112C
Gene name CYC8
Aliases CRT8, SSN6, [OCT1+], [OCT]
Feature type ORF, Verified
Coordinates Chr II:465770..462870
Primary SGDID S000000316

Description of YBR112C: General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters; can form the prion [OCT+][1][2][3]


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Other Interactions

Other Topic: functional dependence Other Interactions interaction with Nrg1
Repression by LexA-Nrg1 of a heterologous promoter containing lexA binding sites depends on Cyc8/Ssn6. [4] [5]


Physical interaction with Nrg1
Nrg1 interacts with Ssn6/Cyc8 in the two-hybrid system, and in GST pull-down experiments. [4] [5]



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  1. Patel BK, et al. (2009) The yeast global transcriptional co-repressor protein Cyc8 can propagate as a prion. Nat Cell Biol 11(3):344-9 SGD PMID 19219034
  2. Proft M and Struhl K (2002) Hog1 kinase converts the Sko1-Cyc8-Tup1 repressor complex into an activator that recruits SAGA and SWI/SNF in response to osmotic stress. Mol Cell 9(6):1307-17 SGD PMID 12086627
  3. Smith RL and Johnson AD (2000) Turning genes off by Ssn6-Tup1: a conserved system of transcriptional repression in eukaryotes. Trends Biochem Sci 25(7):325-30 SGD PMID 10871883
  4. 4.0 4.1 Park SH, et al. (1999) Nrg1 is a transcriptional repressor for glucose repression of STA1 gene expression in Saccharomyces cerevisiae. Mol Cell Biol 19(3):2044-50 SGD PMID 10022891
  5. 5.0 5.1 submitted by Valmik K. Vyas on 2003-02-12

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