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Systematic name YBR103W
Gene name SIF2
Aliases EMB1
Feature type ORF, Verified
Coordinates Chr II:447703..449310
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Description of YBR103W: WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus[1][2][3]

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  1. Gasser SM, et al. (1998) Nuclear organization and silencing: trafficking of Sir proteins. Novartis Found Symp 214():114-26; discussion 126-32 SGD PMID 9601014
  2. Pijnappel WW, et al. (2001) The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program. Genes Dev 15(22):2991-3004 SGD PMID 11711434
  3. Cockell M, et al. (1998) Sif2p interacts with Sir4p amino-terminal domain and antagonizes telomeric silencing in yeast. Curr Biol 8(13):787-90 SGD PMID 9651685

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