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Systematic name YBR089C-A
Gene name NHP6B
Aliases YBR090C-A
Feature type ORF, Verified
Coordinates Chr II:426489..426190
Primary SGDID S000002157

Description of YBR089C-A: High-mobility group (HMG) protein that binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2[1][2][3][4][5]


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  1. Paull TT, et al. (1996) Yeast HMG proteins NHP6A/B potentiate promoter-specific transcriptional activation in vivo and assembly of preinitiation complexes in vitro. Genes Dev 10(21):2769-81 SGD PMID 8946917
  2. Rhoades AR, et al. (2004) Structural features of nucleosomes reorganized by yeast FACT and its HMG box component, Nhp6. Mol Cell Biol 24(9):3907-17 SGD PMID 15082784
  3. Stillman DJ (2010) Nhp6: A small but powerful effector of chromatin structure in Saccharomyces cerevisiae. Biochim Biophys Acta 1799(1-2):175-180 SGD PMID 20123079
  4. Thomas JO (2001) HMG1 and 2: architectural DNA-binding proteins. Biochem Soc Trans 29(Pt 4):395-401 SGD PMID 11497996
  5. Xin H, et al. (2009) yFACT induces global accessibility of nucleosomal DNA without H2A-H2B displacement. Mol Cell 35(3):365-76 SGD PMID 19683499

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