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Systematic name YBR041W
Gene name FAT1
Feature type ORF, Verified
Coordinates Chr II:318266..320275
Primary SGDID S000000245

Description of YBR041W: Very long chain fatty acyl-CoA synthetase and long chain fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of long chain fatty acids[1][2][3][4][5]


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  1. Dirusso CC, et al. (2000) Murine FATP alleviates growth and biochemical deficiencies of yeast fat1Delta strains. Eur J Biochem 267(14):4422-33 SGD PMID 10880966
  2. Faergeman NJ, et al. (1997) Disruption of the Saccharomyces cerevisiae homologue to the murine fatty acid transport protein impairs uptake and growth on long-chain fatty acids. J Biol Chem 272(13):8531-8 SGD PMID 9079682
  3. Watkins PA, et al. (1998) Disruption of the Saccharomyces cerevisiae FAT1 gene decreases very long-chain fatty acyl-CoA synthetase activity and elevates intracellular very long-chain fatty acid concentrations. J Biol Chem 273(29):18210-9 SGD PMID 9660783
  4. Zou Z, et al. (2002) Fatty acid transport in Saccharomyces cerevisiae. Directed mutagenesis of FAT1 distinguishes the biochemical activities associated with Fat1p. J Biol Chem 277(34):31062-71 SGD PMID 12052836
  5. Zou Z, et al. (2003) Vectorial acylation in Saccharomyces cerevisiae. Fat1p and fatty acyl-CoA synthetase are interacting components of a fatty acid import complex. J Biol Chem 278(18):16414-22 SGD PMID 12601005

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